Clinical trial · Interventional
Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief
Adapting Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief: The MORE Relief Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260926-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate whether or not mindfulness-based interventions/MBIs may help reduce chronic pain in participants who have cancer-related chronic pain. MBIs are therapeutic programs that use mindfulness meditation practices to help people focus on the present moment, as well as encourage acceptance of thoughts, emotions, and body sensations. The researchers think that an MBI treatment called Mindfulness-oriented Recovery Enhancement (MORE) may help people who are experiencing cancer-related chronic pain.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Pain | — | UNRESOLVED | — |
| Chronic Pain | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MORE treatments | Behavioral | — | UNRESOLVED |
| Standard of Care for Pain Management | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- PLACEBO_COMPARATOR
- label
- Wait List Control (WLC) Usual Care Procedure
- description
- Participants in the WLC group continue to receive their standard medical care and pain management as prescribed by their physicians or other health care providers.
- interventionNames
- Other: Standard of Care for Pain Management
- type
- EXPERIMENTAL
- label
- 16-hour MORE treatments
- description
- Patients in the 16-hour MORE format will receive one 2hrs treatment a week for 8 consecutive weeks (as per study schema: from week 1 to week 8).
- interventionNames
- Behavioral: MORE treatments
- type
- EXPERIMENTAL
- label
- 8-hour MORE treatments
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * English speaking * Age ≥ 18 years or older * A history of cancer with no restrictions placed on type of cancer * Determined to be either no-evidence of disease or stable oncological disease by referring or study physicians/advanced practice providers * Having a pain (musculoskeletal, generalized, or neuropathic) rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week * Having had pain for at least 3 months and at least 15 days with pain in the preceding 30 days * Willing to adhere to all study-related procedures, including randomization to one of two treatment arms: MORE or WLC * Ability to attend video-call session and a quiet/private location Exclusion Criteria: * Active suicidality or schizophrenia * Plan to initiate palliative radiation or interventional pain procedure within the next 12 weeks * Cognitive impairment preventing completing PRO independently or participate in virtual MORE as evaluated by study clinicians
References
Publications (1)
- DERIVEDBryl KL, Hanley AW, Baser RE, Desai K, Dowd M, Li Q, Sandweiss B, Garland EL, Mao JJ. Mindfulness-Oriented Recovery Enhancement for Cancer Pain Relief: Pilot Randomized Controlled Trial. J Pain Symptom Manage. 2026 Apr;71(4):547-559. doi: 10.1016/j.jpainsymman.2025.12.024. Epub 2026 Jan 3. PMID 41490669