Clinical trial · Interventional
Effectiveness of Thyme Honey in Management of Xerostomia in Post Radiation Cancer Patients
Effectiveness of Thyme Honey in Management of Xerostomia in Post Radiation Cancer Patients A Randomized Controlled Clinical Trial With a Biochemical Assessment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Xerostomia is the most frequent complication among patients who receive radiotherapy (RT) . The prevalence of xerostomia has been reported to be from 73.5% to 93% (Kakoei S.,2012). Damage to normal tissues can result by radiotherapy as it is not selective to cancer cells, and so affecting the quality of life of patients. Honey is one of the methods studied by CIM for management of HNC treatment side effects due to its properties. (Brennan et al., 2002; Clarkson et al., 2007; Furness et al., 2011;Hackett et al., 2015). Thyme honey is a new alternative for management of xerostomia, which is a propolis gel product. Thyme honey is a variety of monofloral honey made from the nectar and pollen of thyme flowers. It has a strong antioxidant, antibacterial, antifungal and immuno modulating health effects. Due to the high sugar concentration in honey, it is believed that its presence in the oral cavity has a sialogogue effect, stimulating the salivary glands to produce saliva.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer Patients | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| saline mouth rinse | Drug | — | UNRESOLVED |
| thyme honey mouth rinse | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- thyme honey
- description
- oral rinses (20 ml of thyme honey diluted in 100 ml of purified water) 3 times per day starting in the 4th week of radiotherapy and for one month after completion of radiotherapy. (Charalambous et al.,2017)
- interventionNames
- Drug: thyme honey mouth rinse
- type
- ACTIVE_COMPARATOR
- label
- Saline
- description
- oral rinses with saline 3 times per day starting in the 4th week of radiotherapy and for one month after completion of radiotherapy.
- interventionNames
- Drug: saline mouth rinse
Primary outcomes (1)
- measure
- subjective dry mouth score
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 25 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Patients referred to non-palliative head and neck radiotherapy * Total dose of radiation received (50-70 Gy) * Patients with complaint of xerostomia * Age 25-65 years old * Objective dry mouth score from ( 2-5) * Subjective dry mouth score from (1-4) * Undergoing radiotherapy for at least three weeks * Can independently complete the questionnaire Exclusion Criteria: * Have confirmed systemic diseases or medications associated with xerostomia * Have a known allergy to honey * Patients who had salivary glands removal surgery * Patients with salivary gland diseases or malignancy * Vulnerable groups such as pregnant females, prisoners, mentally and physically handicapped individuals.
References
Publications (0)
Data not yet available