A Study of Creatine Combined With Curcumin in the Intervention of Early Cachexia in Upper Gastrointestinal Tumors

Cachexia is a common complication of various advanced malignant tumors, which seriously affects the quality of life and survival time of patients. In view of the clinical problem of non-nutritional response in patients with cachexia, the investigators plan to carry out a clinical case-control study on the intervention of creatine combined with curcumin in participants with cachexia. On the whole, the investigators limited the study subjects to upper digestive tract tumors and diagnosed participants with early cachexia. The main purpose of this study is to determine whether the combination of the two can play a positive and stable role in inhibiting the inflammation of cachexia and improving metabolic status, so that basic nutrition can play a role, in order to reduce the level of skeletal muscle consumption, maintain weight, improve quality of life, save medical costs and extend survival time.

Sex

All

Minimum age

18 Years

Maximum age

80 Years

Inclusion Criteria:

* Clinical diagnosis of advanced tumors of the upper digestive tract with untreatable or postoperative recurrence of esophageal and gastric cancer III-IV
* Meet the diagnostic criteria of early cachexia (anorexia and metabolic changes, involuntary body mass reduction ≤5% within 6 months)
* Radiotherapy, chemotherapy or immunotherapy in our hospital
* Understand and fill in a variety of rating scales
* Informed consent, voluntary participation in this study

Exclusion Criteria:

* Neoadjuvant chemotherapy patients
* Intestinal obstruction or gastrointestinal bleeding
* Severe heart, lung and renal insufficiency
* Coagulopathy
* Clinical diagnosis with diabetes and other metabolic diseases
* The expected survival time is less than 1 month
* With cognitive dysfunction or poor coordination
* Allergy to creatine or curcumin
* With a history of drug abuse
* Doctors or researchers deem unsuitable for study participation