Clinical trial · Observational
Primary Tumor Burden Score:A Novel Staging Parameter for ESCC After nCRT
Primary Tumor Burden Score: A Novel Staging Parameter Superior to ypT-category for Esophageal Squamous Cell Carcinoma After Neoadjuvant Chemoradiotherapy
NCT05839002CI-TRIAL-00066113completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this case-only study, the investigators try to define a novel staging parameter, the Primary Tumor Burden Score (PTBS).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neoplasm, Esophagus | Esophageal Neoplasm | ALIAS | 0.90 |
| Neoplasm, Squamous Cell | Squamous Cell Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| nCRT | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Training cohort
- description
- Training cohort will be used to find the best calculation and cut-off values for PTBS in ESCC after nCRT.
- interventionNames
- Procedure: nCRT
- label
- Validation cohort
- description
- The study's conclusion will be verified in Zhongshan Hospital Xiamen branch.
- interventionNames
- Procedure: nCRT
Primary outcomes (1)
- measure
- Five-year survival of patients
- timeFrame
- From surgery to the end of follow-up(at least 5 years later)
- description
- The survival of the patients was recorded by follow-up for five years after surgery.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 79 Years
Show eligibility criteria text
Inclusion Criteria: \- Neoadjuvant chemoradiotherapy and surgical resection of esophageal squamous cell carcinoma Exclusion Criteria: * Patients receiving neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma without surgical resection
References
Publications (1)
- DERIVEDHuang X, Jiang D, Sun T, Zhou G, Zeng Z, Zhang S, Lin M, Fan H, Jian Z, You R, Liu F, Wu M, Xu W, Tang H, Hou Y, Tan L. Primary Tumour Burden Score: A Novel Staging Parameter for Oesophageal Squamous Cell Carcinoma after Neoadjuvant Chemoradiotherapy. Eur J Cardiothorac Surg. 2025 Sep 2;67(9):ezaf254. doi: 10.1093/ejcts/ezaf254. PMID 40758472