Clinical trial · Observational
Prognostic Models for HCC Based on Tumor Micronecrosis
Development and Validation of Novel Models Including Tumor Micronecrosis for Predicting the Postoperative Survival of Patients With Hepatocellular Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The heterogeneity of hepatocellular carcinoma (HCC) leads to the unsatisfying predicting performance of current staging systems. HCC patients with pathological tumor micronecrosis have immunosuppressive microenvironment. We aimed to develop novel prognostic models by integrating micronecrosis to more precisely predict the survival of HCC patients after hepatectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| observing whether HCC patients having tumor micronecrosis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- training cohort
- description
- HCC patients receiving curative hepatic resection
- interventionNames
- Other: observing whether HCC patients having tumor micronecrosis
- label
- validation cohort
- description
- HCC patients receiving curative hepatic resection
- interventionNames
- Other: observing whether HCC patients having tumor micronecrosis
Primary outcomes (1)
- measure
- the Harrell concordance index (C-index)
- timeFrame
- Up to 5 years
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: 1. pathologically diagnosed as HCC; 2. curative hepatectomy with R0 resection; 3. conserved liver function with Child Pugh class A or B Exclusion Criteria: 1. with macrovascular invasion or extrahepatic metastasis; 2. receiving other anti-tumor treatments such as TACE or systemic drugs; 3. with other primary cancers; 4. incomplete follow-up data; 5. without sufficient formalin-fixed, paraffin-embedded (FFPE) specimens for micronecrosis evaluation
References
Publications (0)
Data not yet available