Clinical trial · Observational
Anal Cancer Risk In Women
The Role of Early Detection and Treatment of Anal Intraepithelial Neoplasia in the Prevention of Anal Squamous Cell Carcinoma in Women: Establishing the Disease Burden in Women With Genital Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a retrospective cross-sectional study involving the analysis of Cancer Registry Data. As part of this study, cancer registration data collated by the National Cancer Registration and Analysis Service (NCRAS; the national cancer registry in England), via NHS Digital data access request service (DARS), will be analysed on all female patients aged between 25-90+ years in England with a registered diagnosis of anal and vaginal and/or vulvar and/or cervical cancer and/or high grade squamous intraepithelial lesions (HSIL) between 2001 and 2019. For these patients information on age at diagnosis, ethnicity, deprivation, performance status, stage of the cancer at diagnosis, the date of each diagnosis, the treatment received for the diagnosis and the route to diagnosis, will be analysed. Additionally, the total number of women/year (between 1995 and 2019), in England, aged between 25-90+ years with a diagnosis of anal, vulvar, vaginal and cervical cancer as well as their respective HSILs will be requested. Together this data will be used to establish the incidence of anal cancer and HSIL in women with genital cancers and/or HSILs, the progression timelines between the different pathologies, as well as identify relevant sociodemographic risk factors in this patient group.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anal Cancer | Malignant Anal Neoplasm | CURATED_EXACT | 0.92 |
| Anal Intraepithelial Neoplasia | Anal Intraepithelial Neoplasia | ONTOLOGY_EXACT | 0.98 |
| Genital Cancer | — | UNRESOLVED | — |
| Genital Neoplasm | — | UNRESOLVED | — |
| Human Papilloma Virus | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dual Pathology | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- The incidence of anal HSIL and cancer in women with genital HSIL and/cancer in England
- timeFrame
- 2001- 2019
- description
- as above
Secondary outcomes (3)
- measure
- he risk of anal HSIL and/or SCC in women with genital HSILs and/or SCC in England
- timeFrame
- 2001-2019
- description
- as above
- measure
- The relationship between the incidence of multizonal anogenital disease and specific sociodemographic risk factors.
- timeFrame
- 2001-2019
- description
- as above
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 25 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Women aged 25-90+ years of age. * Women diagnosed with anal cancer and/or HSIL between 2001 and 2019. * The anogenital cancer must be a squamous cell carcinoma. * Women with a diagnosis of anal cancer and/or HSIL and: 1. vaginal cancer and/ or HSIL 2. vulvar cancer and/or HSIL 3. cervical cancer and/or HSIL 4. vaginal and vulvar cancer and/or HSIL 5. vaginal and cervical cancer and/or HSIL 6. vulvar and cervical cancer and/or HSIL 7. vaginal, cervical and vulvar cancer and/or HSIL Exclusion Criteria: * Men with a diagnosis of anal HSIL and/or SCC. * Women aged outside of the 25-90+ years bracket. * Women diagnosed with anal cancer or HSIL before 2001 and after 2019. * Women with genital or anal cancer which is not a squamous cell carcinoma.
References
Publications (0)
Data not yet available