Clinical trial · Interventional
Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients
The Impact of Intravenous Administration of Perioperative Acetaminophen and Ibuprofen Combination (Maxigesic®) on Postoperative Delirium in Elderly Patients Undergoing Minimally Invasive Lung Segmentectomy or Lobectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): The study was terminated early owing to challenges in completing the research registration process.
Summary
Brief summary (as posted)
The primary aim of this interventional study is to investigate the impact of perioperative administration of Maxigesic (combination of acetaminophen and ibuprofen) on delirium after minimally invasive lung surgery in elderly patients. The Maxigesic group receives a total of 5 doses of Maxigesic (20mg/kg, maximum dose per serving: 1g) every 6 h from immediately after anesthesia induction. The control group receives the same volume of normal saline. Researchers compare the incidence and severity of postoperative delirium for 5 days after surgery.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Aged | — | UNRESOLVED | — |
| Delirium | — | UNRESOLVED | — |
| Lung Neoplasms | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Robotic Surgical Procedures | — | UNRESOLVED | — |
| Thoracic Surgery, Video-Assisted | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Acetaminophen and Ibuprofen | Drug | — | UNRESOLVED |
| Normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Maxigesic group
- interventionNames
- Drug: Acetaminophen and Ibuprofen
- type
- PLACEBO_COMPARATOR
- label
- Control group
- interventionNames
- Drug: Normal saline
Primary outcomes (1)
- measure
- Incidence of postoperative delirium(POD)
- timeFrame
- From immediately after surgery to 5 days after surgery
- description
- Confusion assessment method(CAM)/Confusion Assessment Method for the ICU (CAM-ICU) or delirium record on electrical medical record(EMR) will be used for the evaluation of POD.
Secondary outcomes (12)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged 65 years or older undergoing minimally invasive lung lobectomy or segmentectomy Exclusion Criteria: * Hypersensitivity to the main ingredients and additives of Maxigesic * Hypersensitivity to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) * Alcoholism / Alcohol intoxication * Severe hematological abnormalities * Bleeding tendency (e.g., Spontaneous bleeding) * Severe hepatic dysfunction (AST, AST ≥2.5 \* upper normal limit(UNL) or Total bilirubin ≥3.0 mg/dl) * Severe renal dysfunction (eGFR \<30 ml/min/1.73m2 or Dialysis) * Severe heart failure (Left ventricle ejection fraction \<30%) * Uncontrolled hypertension(HTN) (Systolic blood pressure \>180 mmHg) * Symptomatic asthma in need of treatment * Anticoagulants or antiplatelet agents are maintained for up to 5 days before surgery * Barbiturates or tricyclic antidepressants (TCAs) * High-dose methotrexate (MTX) for cancer treatment * Preoperative cognitive impairment, dementia, or delirium * Inability to understand the research and instructions for this study
References
Publications (0)
Data not yet available