Clinical trial · Interventional
Advanced Glycation End Products and Dietary Intervention in Polycystic Ovary Patients
Effect of Dietary Intervention on Serum Advanced Glycation End Products and Metabolic Profile in Polycystic Ovary Syndrome Patients
NCT05830487CI-TRIAL-00065958unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Recently, the negative effects of advanced glycation end products on the pathophysiology of some diseases have attracted attention. This study was planned to evaluate the effect of dietary intervention and weight loss on serum advanced glycation and disease pathogenesis in patients with polycystic ovary syndrome.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Diet Habit | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Energy and fat-reduced normal diet | Behavioral | — | UNRESOLVED |
| Low AGE diet with reduced energy and fat | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Low AGE diet with reduced energy and fat
- description
- Low advanced glycation end products diet with reduced energy and fat
- interventionNames
- Behavioral: Low AGE diet with reduced energy and fat
- type
- EXPERIMENTAL
- label
- Energy and fat-reduced normal diet
- description
- only energy and fat-reduced diet, advanced glycation end products intake will not be interfered with.
- interventionNames
- Behavioral: Energy and fat-reduced normal diet
Primary outcomes (5)
- measure
- Serum advanced glycation end products levels
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 19 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria:• Being diagnosed with PCOS Being between the ages of 19-35 Having a body mass index of more than 25 kg/m2 Volunteering to work \- Exclusion Criteria: * Presence of chronic disease (Diabetes, Hypertension, Atherosclerotic heart diseases, gastrointestinal system diseases..) * Being in pregnancy-lactation or menopause period * Using oral contraceptive medication * Using vitamin-mineral support * Receiving a special dietary treatment * To have applied a weight loss diet in the last 3 months * To smoke
References
Publications (1)
- DERIVEDOzdemir M, Mumusoglu S, Bilgic P. Comparison of Metabolic and Hormonal Profiles between Low-Advanced Glycation End Products (AGEs) and Standard AGEs-Containing Weight-Loss Diets in Overweight Phenotype-A PCOS Patients: A Randomized Clinical Trial. Reprod Sci. 2025 Apr;32(4):1190-1201. doi: 10.1007/s43032-025-01808-8. Epub 2025 Feb 14. PMID 39953370