The IIT Study of Evaluation of P-IL-2 Single Agent and With Anti-PD-1

Inclusion Criteria:

1. Willing and able to follow study procedures , and sign a written informed consent form;
2. Males or females aged 18-75 years old at the time of signing the ICF;
3. Expected survival time ≥ 12 weeks.
4. Physical condition score ECOG ≤ 1.
5. There is still disease progression, intolerance or lack of effective standard treatment under standard treatment. Patients with advanced malignant solid tumor confirmed by pathology (recurrence and / or metastasis); at least 1 Measurable lesions in accordance with RECIST v1.1 or iRECIST standards.
6. Before the first administration, it had recovered from the toxic effects of the last treatment, and the researchers determined that the corresponding AE did not have a safety risk.
7. Organ and bone marrow function levels must meet the following requirements:

   Bone marrow: absolute neutrophil count (ANC) ≥ 1.5 × 109 ppm L, specified value (according to Group determination, see Appendix 11 for instructions on platelet count during the screening period), platelets Count ≥ 100x109 shock L, hemoglobin ≥ 90g/L, and no blood transfusion within 14 days before the first administration.
8. Male subjects and female subjects of childbearing age from the signing of informed consent form to the end of drug research. Voluntary use of effective contraceptive measures within 5 months after secondary use.

Exclusion Criteria:

1. Past or present suffering from other types of malignant tumors.
2. Known to be allergic to research drugs or any of their excipients, or to be too strict with other monoclonal antibodies.Severe anaphylaxis (NCI-CTCAE 5.0 grade ≥ 3).
3. People have hemorrhagic diseases or have hemorrhagic tendencies.
4. Received any of the following treatments or drugs before the first study:

   * large surgery or severe trauma occurred within 4 weeks before the first study of drug treatment.
   * previous use of immunosuppressive drugs within 2 months prior to the first study, excluding nasal spray.
   * And inhaled corticosteroids or physiological doses of systemic steroids.
   * to study the Chinese medicine therapy with anti-tumor indications within 2 weeks before drug treatment for the first time.
5. Patients with a history of central nervous system metastasis (non-tumor meningeal metastasis) or spinal cord compression can be enrolled in the study if they have clearly received treatment and have stopped taking anticonvulsants and steroids for 4 weeks or more and have stable clinical manifestations before the first administration of the study.
6. Symptomatic, visceral spread, and short-term risk of life-threatening complications. the patients who underwent puncture and drainage within 3 weeks before the first administration included pleural effusion and abdominal cavity. Patients with effusion and pericardial effusion.
7. Subjects with active, or history of autoimmune diseases that may recur, or patients at high risk. subjects with the following diseases are allowed to join the group:

   * stable type I diabetic patients treated with fixed dose of insulin.
   * autoimmune hypothyroidism which only needs hormone replacement therapy.
   * skin diseases that do not require systemic treatment.
   * cured childhood asthma / allergy adult patients without any intervention.
8. Within 6 months before screening, any cardiovascular disease met any of the following criteria:

   * congestive heart failure with heart function ≥ New York Heart Association (NYHA) Class II; left ventricular ejection. Blood fraction (LVEF) \< 50%.
   * severe arrhythmias requiring drug treatment.
   * QTcF (Fridericia formula) male \> 450ms, female \> 470ms, or exist risk factors of apical torsion ventricular tachycardia are of clinical significance .
   * myocardial infarction and severe / unstable angina pectoris occurred within 6 months before administration.
   * history of thromboembolism with grade 3 or more in the past 2 years, or is being received because of a high risk of thrombosis.

   Receive thrombolytic or anticoagulant therapy.
9. Currently suffering from sudden lung disease, interstitial lung disease or pneumonia, pulmonary fibrosis, acute lung disease, etc., except local interstitial pneumonia caused by radiotherapy.
10. Uncontrolled systemic diseases .
11. history of human immunodeficiency virus infection, or suffer from other acquired, congenital immunodeficiency. Disease, or a history of organ transplantation, or a history of stem cell transplantation;
12. Evidence of active infection.
13. Previous history of neurological or mental disorders, or known history of psychotropic substance abuse and alcoholism.

    History or history of drug use.
14. Received any research drug within 4 weeks before the first administration, or participated in another clinical trial at the same time.
15. Female patients who are pregnant or lactating, or whose baseline pregnancy test results are positive.
16. The researchers believe that it is not suitable for patients to be included in this study.