Almonertinib in the First-line Treatment of Patients of NSCLC With Poor Performance Status

Inclusion Criteria:

1. The subjects voluntarily joined the study, signed the informed consent form, had good compliance, and cooperated with the follow-up.
2. Male or female who is over 18 years old.
3. Malignant tumorsr proved by pathology.
4. NSCLC patients with EGFR mutation (19 deletion/21 L858R point mutation) or primary T790M mutation in pre-enrollment genetic testing.
5. PS score of 2-4; this score is caused by complications caused by the tumor and cannot be improved by any non-anti-tumor means.
6. Patients with brain metastases may be enrolled at the discretion of the investigator.
7. Appropriate organ system function.

Exclusion Criteria:

1. Patients who have previously used any antineoplastic drugs。
2. Small cell lung cancer (including lung cancer mixed with small cell lung cancer and non-small cell lung cancer);
3. Genetic testing results in patients with rare EGFR genotypes (G719X, E709X, Del18 on exon 18, Ins19 on exon 19, Ins20, S768I on exon 20, and L861Q on exon 21).
4. Patients with other mutations (ALK, Ros-1, C-MET).
5. Imperfection of upper gastrointestinal physiology, or absorption disorder syndrome, or inability to tolerate oral drugs, or active peptic ulcer;
6. Participated in other clinical trials within 4 weeks before the start of the study;
7. patients with hypertension who cannot control well through single antihypertensive medication (systolic blood pressure \> 140mmhg, diastolic blood pressure \> 90mmhg), myocardial ischemia or myocardial infarction, arrhythmia (including QT interval \> 440 ms) or cardiac insufficiency;
8. Allergic to any ingredient in the drug;
9. Patients with abnormal coagulation function, receiving thrombolysis or anticoagulation therapy, bleeding tendency or have clear gastrointestinal bleeding concerns;
10. Hyperactive/venous thrombosis events, such as cerebrovascular accident (including transient ischemic attack), deep venous thrombosis and pulmonary embolism occurred in 6 months before the start of the study;
11. Wound or fracture has not been healed for a long time;
12. urinary protein was greater than ++ and 24-hour urinary protein quantification #1.0 g.
13. Severe or uncontrolled infections;
14. Substance abuse or mental disorder;
15. Objective evidence of a history of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radioactive pneumonia, drug-related pneumonia, and severe impairment of pulmonary function;
16. Immunodeficiency, including being HIV-positive, or having other acquired, congenital immunodeficiency diseases, or having a history of organ transplantation;
17. Other malignant tumors within 5 years, except cured basal cell carcinoma of the skin and orthotopic carcinoma of the cervix;
18. Who have received VEGFR inhibitors, such as sorafenib and sunitinib, etc.;
19. pregnant or lactating women;
20. the researchers considered it unsuitable for inclusion。