Clinical trial · Interventional
Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery
A Prospective, Randomized Controlled Study to Compare the Effect of Sevoflurane and Propofol for Maintenance of Anesthesia on Postoperative Recovery After Transsphenoidal Resection of Pituitary Adenoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Currently, total intravenous anesthesia (TIVA) and inhaled anesthesia are both commonly used for transsphenoidal pituitary adenoma resection. However, optimal choice for anesthesia maintenance in transsphenoidal surgery remains unclear. Previous studies focusing on this question provided fragmentary assessment and controversial results. The goal of this clinical trial is to investigate whether propofol and sevoflurane have different effect on post-anesthetic recovery after transsphenoidal resection of pituitary adenoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pituitary Adenoma | Pituitary Neuroendocrine Tumor | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| propofol | Drug | — | UNRESOLVED |
| sevoflurane | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- sevoflurane
- description
- Anesthesia is maintained with sevoflurane.
- interventionNames
- Drug: sevoflurane
- type
- EXPERIMENTAL
- label
- propofol
- description
- Anesthesia is maintained with continuous infusion of propofol.
- interventionNames
- Drug: propofol
Primary outcomes (1)
- measure
- 15-item quality of recovery score (QoR-15)
- timeFrame
- 24 hours after end of surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. Men or women, aged from 18 to 70 2. American Society of Anesthesiologists (ASA) class I - III 3. Patients scheduled for transsphenoidal surgery requiring general anesthesia managed with endotracheal intubation Exclusion Criteria: 1. Patients allergic or contraindicated to sevoflurane, propofol, or other drugs used during surgery 2. Severe pulmonary disease, saturation of peripheral oxygen (SpO2) \< 90% 3. Severe nervous system disease with consciousness disorder 4. Patients scheduled for intensive care unit (ICU) after surgery 5. Pregnancy
References
Publications (4)
- BACKGROUNDCafiero T, Cavallo LM, Frangiosa A, Burrelli R, Gargiulo G, Cappabianca P, de Divitiis E. Clinical comparison of remifentanil-sevoflurane vs. remifentanil-propofol for endoscopic endonasal transphenoidal surgery. Eur J Anaesthesiol. 2007 May;24(5):441-6. doi: 10.1017/S0265021506002080. Epub 2007 Mar 12. PMID 17376252
- BACKGROUNDAli Z, Prabhakar H, Bithal PK, Dash HH. Bispectral index-guided administration of anesthesia for transsphenoidal resection of pituitary tumors: a comparison of 3 anesthetic techniques. J Neurosurg Anesthesiol. 2009 Jan;21(1):10-5. doi: 10.1097/ANA.0b013e3181855732. PMID 19098618
- BACKGROUNDKim DH, Min KT, Kim EH, Choi YS, Choi SH. Comparison of the effects of inhalational and total intravenous anesthesia on quality of recovery in patients undergoing endoscopic transsphenoidal pituitary surgery: a randomized controlled trial. Int J Med Sci. 2022 Jun 13;19(6):1056-1064. doi: 10.7150/ijms.72758. eCollection 2022. PMID 35813289
- DERIVEDFeng Y, Zhang Y, Lian W, Xue Y, Ma M, Yu X, Guo X, Ma L, Xing B, Huang Y. A randomized controlled trial to compare the effects of sevoflurane and propofol for maintenance of anesthesia on postoperative recovery quality in patients undergoing transsphenoidal resection of pituitary adenoma. BMC Anesthesiol. 2025 Aug 4;25(1):392. doi: 10.1186/s12871-025-03263-z. PMID 40760415