Clinical trial · Observational
Role of the Tumor Microenvironment in Aggressive Meningiomas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Meningiomas are the most common primary tumors of the central nervous system in adults. High-grade forms have a high frequency of neurofibromatosis 2 (NF2) mutations and represent 25% of meningiomas, with multiple recurrences associated with morbidity and reduced survival without medical options, including immunotherapy. The meninges play a key role in neuro-immune communication through the diversity of their immune cells and the presence of meningeal lymphatic vessels (MLV). Recent data, including from our team, shows frequent infiltration of lymphocytes and myeloid cells specific to benign meningiomas. Our hypothesis is that the immune microenvironment composed of meningeal immune cells and MLVs regulates the malignant histological progression of NF2-mutated meningiomas and their immune surveillance evasion behavior This study aims to characterize the different cellular populations of the meningioma microenvironment. We will describe the exact participation of immune and vascular cell populations in the initiation and progression of meningioma, using MRI imaging and surgical biopsies of the dura mater and meningioma in patients undergoing neurosurgery for meningioma resection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Meningioma | Meningioma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Surgical waste and Data collect | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- patients treated for meningioma
- description
- Samples required for the study will be obtained from surgical waste of patients who underwent meningioma resection.
- interventionNames
- Other: Surgical waste and Data collect
Primary outcomes (1)
- measure
- Cellular phenotypes and their interactions in the tissue microenvironment
- timeFrame
- one day
- description
- Characterized by combining different techniques and analysis systems (RNA-seq, RNAScope, Hyperion, Hyperion immunostaining) using samples from various grades of meningiomas and associated dura mater
Secondary outcomes (5)
- measure
- Expressed genes in meningioma
- timeFrame
- one day
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients who underwent surgery for the resection of a meningioma. 2. Patients with meningiomas located at the convexity and parasagittal regions. 3. Patients aged 18 years or older. 4. Patients who were informed of the study and did not express opposition to their participation. Exclusion Criteria: * Individuals under legal protection (guardianship, trusteeship) safeguarded by justice
References
Publications (0)
Data not yet available