Clinical trial · Observational
Salivary LINC00657 as a Diagnostic Biomarker for Oral Squamous Cell Carcinoma
NCT05821179CI-TRIAL-00065829completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study was designed to verify the role of salivary LINC00657 as a diagnostic marker in oral squamous cell carcinoma (OSCC) patients as compared to oral lichen planus (OLP) (as an example of oral potentially malignant lesions) and normal individuals, and to show its relation to miR-106a. A total of 36 participants were included.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Squamous Cell Carcinoma | Oral Cavity Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (3)
- label
- Group I
- description
- 12 patients diagnosed with OSCC.
- label
- Group II
- description
- 12 patients diagnosed with OLP.
- label
- Group III
- description
- 12 systemically free individuals with no oral mucosal lesions.
Primary outcomes (1)
- measure
- LINC00657 level in salivary samples from all participants measured using PCR
- timeFrame
- level of miR-106a is measured after the completion of all salivary sample collection carried at the 1 day of enrollment of subjects in the investigation after diagnosis confirmation
- description
- quantitative real-time PCR is used to detect LINC00657 levels in saliva samples from patients with OSCC and OPMD compared to healthy subjects
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * group I : oral squamous cell carcinoma lesions (OSCC) * group II: oral lichen planus lesions (OLP) * group III: systemically healthy volunteers Exclusion Criteria: * oral lesions other than OSCC / OLP in group I and II * any oral lesion in group III * pregnant females
References
Publications (1)
- DERIVEDTarrad NAF, Hassan S, Shaker OG, AbdelKawy M. "Salivary LINC00657 and miRNA-106a as diagnostic biomarkers for oral squamous cell carcinoma, an observational diagnostic study". BMC Oral Health. 2023 Dec 12;23(1):994. doi: 10.1186/s12903-023-03726-0. PMID 38087258