Clinical trial · Observational
Bladder and Bone Effects of Pelvic Radiation Therapy in Childhood Cancer Survivors
Effect of Pelvic Radiation Therapy on the Urinary and Musculoskeletal Systems of Survivors of Childhood Cancer
NCT05818462CI-TRIAL-00101969completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to measure and evaluate the effects of pelvic external beam radiation therapy (EBRT) on lower urinary tract (LUT) function and bone mineralization.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Childhood Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bladder Scan | Diagnostic Test | — | UNRESOLVED |
| DEXA Scan of pelvis and sacral spine | Diagnostic Test | — | UNRESOLVED |
| Dysfunctional Voiding Scoring System Survey | Other | — | UNRESOLVED |
| Urine tests for specific biomarkers | Diagnostic Test | — | UNRESOLVED |
| Uroflow testing | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patients who received EBRT to the pelvis.
- description
- Childhood cancer survivors who were treated with chemotherapy and radiation therapy to the pelvis, with or without surgical intervention. This group will consist of both primary pelvic sarcomas as well as patients who received whole abdominal radiation that included bladder exposure.
- interventionNames
- Diagnostic Test: Uroflow testing
- Diagnostic Test: Bladder Scan
- Other: Dysfunctional Voiding Scoring System Survey
- Diagnostic Test: DEXA Scan of pelvis and sacral spine
- Diagnostic Test: Urine tests for specific biomarkers
- label
- Control cohort.
- description
- Childhood cancer survivors who have been treated for a sarcoma who did not receive pelvic radiation, and were treated with chemotherapy, with or without surgical intervention or radiation therapy (outside of the pelvis). These patients will be matched as closely as possible to Group 1 to match chemotherapy regimens, and sex.
- interventionNames
- Diagnostic Test: Uroflow testing
- Diagnostic Test: Bladder Scan
- Other: Dysfunctional Voiding Scoring System Survey
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 2 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Patients of any age who were treated were diagnosed in 2007 or later and received chemotherapy for solid tumor malignancy, with completion of therapy (whether chemotherapy or radiation) at least one year prior to study enrollment. Exclusion Criteria: * Patients with known dysfunctional voiding prior to cancer treatment. * Patients with tumor resection of bladder, prostate or gynecologic organs will be excluded.
References
Publications (0)
Data not yet available
No reference posted for this study.