Clinical trial · Observational
Vitamin D and Head and Neck Cancer: Impact on Toxicity and Prognosis
Vitamin D and Head and Neck Cancer: Impact on Toxicity and Prognosis: Prospective Multicenter Study of Head-Neck Group of the Italian Association of Radiotherapy and Clinical Oncology (AIRO)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to learn about relation between vitamin D levels in subjects with head and neck cancer. The main question it aims to answer are: * variation of vitamin D levels in the study population at different time points * relation between therapy side effects and vitamin D level * relation between disease outcome and vitamin D level Participants will be followed as per clinical practice
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Head and Neck cancer patients
- description
- candidate to receive definitive or adjuvant radiation therapy with bilateral neck irradiation
Primary outcomes (1)
- measure
- Vitamin D variation
- timeFrame
- 7 weeks
- description
- Difference in vitamin D levels between baseline and during radiotherapy
Secondary outcomes (5)
- measure
- Baseline vitamin D level and radiotherapy toxicity
- timeFrame
- 8 weeks
- description
- Evaluation of the impact of baseline vitamin D levels on acute toxicity (mucositis, dermatitis and weight loss \>10%)
- measure
- Baseline vitamin D level and response
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: histologically proven HNSCC (squamous cell carcinomas), all subsites * non-metastatic locally advanced stages * patients candidate for radical or adjuvant radiotherapy * patients candidate for bilateral neck irradiation * written informed consent Exclusion Criteria: * distant metastases * patients with known disorders of calcium/vitamin D metabolism
References
Publications (0)
Data not yet available