Study on the Efficacy and Safety of MA-BUCY2 Conditioning in High-risk AML Patients Underwent Haplo-HSCT

Inclusion Criteria:

* Meet the diagnostic criteria of 2022 ELN guidelines for high-risk acute myeloid leukemia;
* Patients with allogeneic stem cell transplantation indications;
* Age 18-60 (including upper and lower limits) ;
* No gender limit;
* ECOG score 0\~2 points;
* Flow MRD was negative before transplantation;
* The organ function level must meet the following requirements: a) Liver: aspartate aminotransferase (AST), alanine aminotransferase (ALT) ≤ 3 times the upper limit of normal value (ULN), Total bilirubin (TBIL) ≤ 1.5 × ULN； b) Kidney: blood creatinine ≤ 1.5 × ULN； c) Coagulation function: international normalized ratio (INR) and activated partial thromboplastin time (APTT) ≤ 1.5 × ULN； d) Normal cardiac function: that is, the ECG is normal or abnormal without clinical significance, and the left ventricular ejection fraction (LVEF) is greater than 60 or myocardial zymogram CK-MB is normal, pro-BNP is less than 900 pg/ml;
* The results of serum pregnancy test of female subjects with reproductive ability must be negative before the first use of the test drug;

Exclusion Criteria:

* Previously received doxorubicin or other anthracycline drugs, and the total cumulative dose of doxorubicin was more than 360 mg/m2;
* Hypersensitivity to any study drug or its components;
* Cardiac function and disease meet one of the following conditions:

  1. Long QTc syndrome or QTc interval\>480 ms;
  2. Complete left bundle branch block, II or III degree atrioventricular block;
  3. Serious and uncontrolled arrhythmia requiring drug treatment;
  4. American New York Heart Association rating ≥ III;
  5. Cardiac ejection fraction (LVEF) is less than 60%;
  6. History of myocardial infarction, unstable angina pectoris, severe unstable ventricular arrhythmia or He has any arrhythmia requiring treatment, clinical history of serious pericardial disease, or acute ischemia or activity ECG evidence of abnormal conduction system.;\\
* Active infection of hepatitis B and hepatitis C;
* Human immunodeficiency virus (HIV) infection;
* Patients with other malignant tumors;
* Pregnant and lactating women and patients of childbearing age who are unwilling to take contraceptive measures;
* Have a history of abuse of drugs;
* History of mental illness or cognitive impairment; .Other researchers judged that it was not suitable for this study.