Clinical trial · Interventional
Re-irradiation Therapy of Locally Recurrent Rectal Cancer With Carbon Ion
A Prospective Phase II Clinical Study of Carbon Ion Re-irradiation in Unresectable Locally Recurrent Rectal Cancer
NCT05807984CI-TRIAL-00065491not yet recruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prospective phase II clinical study aim to explore the clinical outcome of patients with unresectable locally recurrent rectal cancer (LRRC) treated with re-irradiation by carbon ion radiotherapy (CIRT)
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
| Recurrent | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Carbon ion radiation therapy DT: 74Gy/20 fractions | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- carbon ion therapy for unresectable local recurrent rectal cancer
- interventionNames
- Radiation: Carbon ion radiation therapy DT: 74Gy/20 fractions
Primary outcomes (1)
- measure
- local control
- timeFrame
- Local control at 3 years after CIRT
- description
- local control rate of the lesion treated by CIRT
Secondary outcomes (2)
- measure
- overall survival
- timeFrame
- 3 years after CIRT or patient died, measured erery 3 months after CIRT
- description
- survival rate after CIRT
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * 1\) pathologically confirmed rectal adenocarcinoma (including mucinous adenocarcinoma and signet-ring cell carcinoma) and LRRC confirmed by biopsy or clinical diagnosis, * 2\) received a radical operation for their primary tumor and regional lymph nodes, * 3\) received chemo-radiation or radiation in pelvic before CIRT, * 4\) received re-irradiation by CIRT after their pelvic radiotherapy. Exclusion Criteria: * 1\) received more than once prior radiotherapy in the same treatment field, * 2\) time to the last radiotherapy was \<1 year, * 3\) space between the lesion to organ at risk (OARs) (bladder or digestive tract) was too close (\<5 mm).
References
Publications (0)
Data not yet available
No reference posted for this study.