Clinical trial · Interventional
Study of Alpha-blockers Alone During Preoperative Preparation in Patients With Pheochromocytoma
Clinical Study of Abandonment of Intravenous Volume Expansion After Preoperative Use of α-blockers in Patients With Adrenal Pheochromocytoma
NCT05803330CI-TRIAL-00065431completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Study of the relationship between hemodynamic stability and preoperative intravenous rehydration in patients with pheochromocytoma
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adrenal Pheochromocytoma | Adrenal Gland Pheochromocytoma | ALIAS | 0.90 |
| Hemodynamic | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Abandonment of intravenous volume expansion during preoperative preparation in patients with pheochromocytoma | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- PXB combined with venous dilation group
- description
- Use of PXB combined with intravenous volume expansion during preoperative preparation in patients with pheochromocytoma
- type
- EXPERIMENTAL
- label
- PXB group
- description
- PXB alone during preoperative preparation in patients with pheochromocytoma
- interventionNames
- Drug: Abandonment of intravenous volume expansion during preoperative preparation in patients with pheochromocytoma
Primary outcomes (1)
- measure
- intraoperative mean arterial pressure
- timeFrame
- During surgery
- description
- an intraoperative mean arterial pressure \<60 mmHg is considered to be hemodynamically unstable
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: Clinical diagnosis of adrenal pheochromocytoma Must be able to swallow tablets Exclusion Criteria: Bilateral or multiple pheochromocytomas. Ectopic pheochromocytoma
References
Publications (4)
- BACKGROUNDMeijs AC, Snel M, Corssmit EPM. Pheochromocytoma/paraganglioma crisis: case series from a tertiary referral center for pheochromocytomas and paragangliomas. Hormones (Athens). 2021 Jun;20(2):395-403. doi: 10.1007/s42000-021-00274-6. Epub 2021 Feb 11. PMID 33575936
- BACKGROUNDChallis BG, Casey RT, Simpson HL, Gurnell M. Is there an optimal preoperative management strategy for phaeochromocytoma/paraganglioma? Clin Endocrinol (Oxf). 2017 Feb;86(2):163-167. doi: 10.1111/cen.13252. Epub 2016 Oct 24. PMID 27696513
- BACKGROUNDRandle RW, Balentine CJ, Pitt SC, Schneider DF, Sippel RS. Selective Versus Non-selective alpha-Blockade Prior to Laparoscopic Adrenalectomy for Pheochromocytoma. Ann Surg Oncol. 2017 Jan;24(1):244-250. doi: 10.1245/s10434-016-5514-7. Epub 2016 Aug 25. PMID 27561909
- BACKGROUNDBihain F, Nomine-Criqui C, Guerci P, Gasman S, Klein M, Brunaud L. Management of Patients with Treatment of Pheochromocytoma: A Critical Appraisal. Cancers (Basel). 2022 Aug 9;14(16):3845. doi: 10.3390/cancers14163845. PMID 36010839