Clinical trial · Interventional
Accelerating Motor Recovering in Patients With SMA Syndrome After Glioma Surgery by Using nrTMS
Beijing Neurosurgical Institute, Beijing, China
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this randomized clinical controlled trial is to learn about whether neuro-navigation repetitive transcranial magnetic stimulation (nrTMS) was useful to accelerate the recovery in patients with SMA syndrome after glioma resection. The main questions aim to answer: * Question 1: Whether the nrTMS was useful to accelerate the recovery of motor function back to the preoperative status in participants with SMA syndrome after glioma resection. * Question 2: Whether the nrTMS was useful to improve postoperative motor function in participants with SMA syndrome after glioma resection. Participants will continue to receive nrTMS treatment or nrTMS sham-treatment for 7 times on the 8th day after glioma resection to determine whether the TMS was helpful for exercise rehabilitation. The investigator will evaluate the effects of nrTMS treatment through the ratio of recovery of motor function and the time that was from the participants suffering SMA syndrome to totally recover the motor function to the status of motor function in pre-operation.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
| Motor Cortex; Lesion | — | UNRESOLVED | — |
| Supplementary Motor Area Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| TMS stimulation sham-treatment | Device | — | UNRESOLVED |
| TMS stimulation treatment | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- TMS treatment
- description
- Using nrTMS coli to stimulate the thumb related motor cortex with high-frequency.
- interventionNames
- Device: TMS stimulation treatment
- type
- SHAM_COMPARATOR
- label
- TMS Sham-treatment
- description
- Using nrTMS sham-coli to stimulate the thumb related motor cortex with high-frequency.
- interventionNames
- Device: TMS stimulation sham-treatment
Primary outcomes (1)
- measure
- Motor function totally recovering in evaluating with MRC (the UK Medical Research Council) muscle strength test
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 25 Years
- Maximum age
- 55 Years
Show eligibility criteria text
Inclusion Criteria: * Inpatients in neurosurgery oncology wards of Beijing Tiantan Hospital * Right-handed, age: 25-55 years old * Tumor located in supplementary motor area * No previous treatment history of central nervous system disease * The patient received awaken craniotomy * Pathological diagnosis is low grade glioma * Volunteer to accept nrTMS treatment Exclusion Criteria: * The tumor grows across the midline to the opposite side * Regarding rs-fMRI data, head movement exceeds 1mm and head deflection exceeds 1 ° * The patient did not have SMA syndrome after operation * Vulnerable or special groups and protective measures, such as pregnant women
References
Publications (2)
- BACKGROUNDNakajima R, Kinoshita M, Yahata T, Nakada M. Recovery time from supplementary motor area syndrome: relationship to postoperative day 7 paralysis and damage of the cingulum. J Neurosurg. 2019 Feb 8;132(3):865-874. doi: 10.3171/2018.10.JNS182391. Print 2020 Mar 1. PMID 30738403
- RESULTFang S, Li L, Weng S, Zhang Z, Fan X, Jiang T, Wang Y. Increasing nodal vulnerability and nodal efficiency implied recovery time prolonging in patients with supplementary motor area syndrome. Hum Brain Mapp. 2022 Sep;43(13):3958-3969. doi: 10.1002/hbm.25896. Epub 2022 May 4. PMID 35507429