Clinical trial · Interventional
Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds
Effectiveness of Topical Morphine Use in Patients With Painful Neoplastic Wounds in the Breast and Head and Neck: Double Blind Randomized Clinical Trial - MorphineGEL
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to compare in compare pain reduction in patients with malignant wounds using morphine gel or lidocaine gel. The main question to be answered is: • Does morphine gel offer better pain control in malignant wounds when compared to lidocaine gel? Participants will answer a questionnaire where they report a note for pain at the site of the malignant wound and then the dressing will be performed by a nurse from the research team. The patient and the nurse do not know which product is being used. At the end of the dressing, the patient answers a new questionnaire. This process will be carried out for 3 days. The researchers will compare the intervention group (morphine gel) and the control group (lidocaine gel) and verify if there is a difference in pain reduction between the two products.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer, Breast | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Cancer Head Neck | — | UNRESOLVED | — |
| Cancer Pain | — | UNRESOLVED | — |
| Wounds and Injuries | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lidocaine Hcl 2% Jelly | Drug | — | UNRESOLVED |
| Morphine Sulfate | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Morphine sulfate
- description
- Topical morphine with hydrogel base.
- interventionNames
- Drug: Morphine Sulfate
- type
- ACTIVE_COMPARATOR
- label
- Lidocaine Hcl 2% jelly
- description
- 2% lidocaine jelly
- interventionNames
- Drug: Lidocaine Hcl 2% Jelly
Primary outcomes (1)
- measure
- Numeric pain rating scale
- timeFrame
- 3 days
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Malignant neoplastic wound in breast or head and neck; * Malignant neoplastic wound with staging \>= II; * KPS \>=30% * Having at least 3 on the numerical pain rating scale (0-10); * Admission time equal to or greater than 48 hours. * Make use of systemic morphine. Exclusion Criteria: * Wound with fistula; * Wound with extensive coagulation necrosis (\>50% of wound area; * Exuding wound \> 1 (PUSH Scale); * Bleeding wound \>1 (VIBe Scale) * Ongoing radiotherapy on the wound.
References
Publications (0)
Data not yet available