Clinical trial · Interventional
The Effects of Two Exercise Interventions on Breast Cancer Patients Undergoing Cardiotoxic Chemotherapies
A Feasibility Study to Examine Two Remotely-monitored Exercise Interventions on Breast Cancer Patients Undergoing Cardiotoxic Chemotherapies
NCT05786014CI-TRIAL-00090919completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine if exercise preconditioning can mitigate the off target effects of chemotherapy treatment on measures of cardiovascular function, inflammatory responses, and quality of life.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Cardiotoxicity | — | UNRESOLVED | — |
| Cardiovascular Diseases | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| High Intensity Interval Exercise | Behavioral | — | UNRESOLVED |
| Moderate Intensity Walking | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Moderate Intensity Walking
- description
- Subjects allocated to moderate intensity walking will be given a gift card to purchase a paid of running shoes. A chest-based heart rate monitor and an activity tracker watch will be provided. Subjects will aim to achieve 150 minutes a week of moderate intensity walking. Subjects will also be receiving text messages, phone calls, and emails from study staff to gauge and encourage subject participation and physical activity.
- interventionNames
- Behavioral: Moderate Intensity Walking
- type
- EXPERIMENTAL
- label
- High Intensity Interval Exercise
- description
- Subjects will receive a recumbent bike to be delivered and assembled to their home as well as a heart rate monitor and activity tracker. Subjects will undergo high intensity interval exercise 3 days a week, with the goal of achieving 85-90% of their heart rate max. Subjects will also be receiving text messages, phone calls, and emails from study staff to gauge and encourage subject participation and physical activity.
- interventionNames
- Behavioral: High Intensity Interval Exercise
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 years or over * diagnosis of breast cancer (Stage I-III or IV with minimal burden) and prescribed chemotherapy (TC (Docetaxel/Cyclophosphamide), AC (Doxorubicin/Cyclophosphamide followed by Paclitaxel), TCHP (Docetaxel, Carboplatin, Trastuzumab, Pertuzumab), TCH (Docetaxel/Carboplatin/Trastuzumab) with or without Pembrolizumab) * Physician clearance for exercise training * Speak/understand English Exclusion Criteria: * previous treatment with cardiotoxic chemotherapy * medical/orthopedic comorbidities that preclude stationary cycling * significant cardiac/renal/hepatic/hematological/pulmonary disease precluding exercise training * unstable angina or myocardial infarction within 4-weeks prior to treatment * complex ventricular arrhythmias or New York Heart Association class IV symptoms * symptomatic severe aortic stenosis * acute pulmonary embolus * acute myocarditis * History of untreated high-risk proliferative retinopathy * History of retinal hemorrhage * uncontrolled hypertension (systolic blood pressure \> 180 mm Hg or diastolic blood pressure \> 120 mm Hg) * severe baseline electrolyte abnormalities * medication non-compliance * uncontrolled metabolic disease (diabetes with fasting blood sugar \>300 mg/dl, thyrotoxicosis, myxedema) * symptomatic peripheral vascular disease * Pregnant women
References
Publications (1)
- DERIVEDWeeldreyer NR, Ellison CC, Mabalot MB, Helms CE, Nealy ZB, Leicht ZS, Abbate A, Brenin CM, Dillon PM, Millard T, Krukowski RA, Zoellner JM, Angadi SS. The effect of two remote exercise programs on cardiorespiratory fitness, cardiac function, and vascular health in patients with breast cancer. Physiol Rep. 2026 Feb;14(4):e70787. doi: 10.14814/phy2.70787. PMID 41704018