SBRT Plus vNKT for Pancreatic Cancer

Inclusion Criteria:

1. Age more than 18 years.
2. Pathological confirmed pancreatic ductal adenocarcinoma.
3. No previous immunotherapy or radiotherapy, or more than one year after the last course of radiotherapy.
4. History of sugery or chemotherapy, and documented disease progressions after these therapies.
5. ECOG performance status of 0-2 points.
6. Normal results of laboratory tests, including WBC ≥4.0×10\^9/L, Neu ≥2.0×10\^9/L, Hb ≥120g/L, Plt ≥100×10\^9/L; AST, ALT \<2.5 times of the upper limit of normal, total bilirubin \<17.1μmol/L, creatinine \<110μmoI/L; international normalized ratio in coagulation test \<2.0
7. Willing to participate in the study and complete follow-up examinations as required.

Exclusion Criteria:

1. History of immunotherapy, or less than one year after the last course of radiotherapy.
2. History of other tumors.
3. Confirmed synchronous multiple tumors.
4. ECOG performance status of more than 2 points.
5. Active inflammatory bowel disease, or peptic ulcer.
6. History of gastrointestinal bleeding or perforation within 6 months.
7. Infections required antibiotics.
8. Positive HBsAg or HCV antibody.
9. Positive HIV antibody.
10. Impaired heart function (NYHA III-IV level), respiratory insufficiency.
11. Confirmed genetic diseases.
12. History of hematologic diseases, including leukemia, lymphoma, myeloma or myelodysplastic syndrome.
13. History of stem cell or organ transplantation.
14. History of autoimmune diseases except leukoderma punctata.
15. Severe anaphylaxis.
16. Long term use of immunosuppressors or steroids.
17. Receiving chemotherapy at the time of screening stage, or participation of other studies.
18. Pregnancy or lactation.
19. Unable to understand the whole procedure of study and provide written informed consent.
20. No comprehensive understanding about patients' immune functions.