Clinical trial · Observational
Subclinical Hypothyroidism and Normogonadotropic Anovulation
Subclinical Hypothyroidism and Ovarian Reserve Indices in Women With Normogonadotropic Anovulation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Thyroid hormones (TH) can modify the functioning of the hypothalamic-pituitary-ovarian axis, affecting the functions of granulosa cells and the development and apoptosis of preantral follicles. TH receptors are present within the oocytes, and TH and anti-thyroid antibodies (ATA) are present in the follicular fluid. Improper thyroid function can cause ovulation disorders, luteal phase failure, impaired endometrial receptivity and result in implantation failures and recurrent miscarriages. While overt hypothyroidism is treated to improve fertility, the effect of subclinical hypothyroidism (SCH) and the presence of circulating ATAs on fertility and obstetric outcomes is uncertain and data on ovarian reserve rates are conflicting. Among the causes of ovulation disorders (group II according to the WHO classification), polycystic ovary syndrome (PCOS) dominates, found in 3-15% of women of reproductive age, and the remaining group of causes is the so-called Hypothalamic-Pituitary-Ovarian Axis Dysfunction (HPOD). The exact etiology of both entities is unknown.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hypothalamic-Pituitary-Ovarian Axis Dysfunction (Disorder) | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Comparison of laboratory test results in women in the 4 study arms | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- 1
- description
- PCOS and SCH
- interventionNames
- Other: Comparison of laboratory test results in women in the 4 study arms
- label
- 2
- description
- PCOH without SCH
- interventionNames
- Other: Comparison of laboratory test results in women in the 4 study arms
- label
- 3
- description
- HPOD and SCH
- interventionNames
- Other: Comparison of laboratory test results in women in the 4 study arms
- label
- 4
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * age 18-45 * irregular periods * infertility due to ovulation disorders * euthyreosis Exclusion Criteria: * diagnosed and treated thyroid dysfunction, * history of thyroidectomy
References
Publications (0)
Data not yet available