Clinical trial · Observational
Gene Expression Of Suppressor Of Cytokines in In Cutaneous Warts
Assessment Of Gene Expression Of Suppressor Of Cytokine 3, Interferons Alpha And Beta In Cutaneous Warts
NCT05781841CI-TRIAL-00079046completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Warts are common epidermal growths caused by various strains of human papilloma virus (HPV). Viral warts are common with a prevalence rate of 7-12%. Human papilloma virus is small non enveloped viruses that contain a double-stranded DNA genome. There are more than 200 HPV genotypes are reported, however, the high-risk types, including HPV genotype-16 (HPV16), 18, 31, and 45, are the causes of 80% of cervical cancers.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Warts | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Detection of expression of IFN-α gene | Diagnostic Test | — | UNRESOLVED |
| Detection of expression of IFN-β gene | Diagnostic Test | — | UNRESOLVED |
| Detection of expression of SOCS3 gene | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- patients with cutaneous warts
- description
- Under complete sterile precautions, Skin biopsy will be taken from patients with wart lesion. The specimen will be put in sterile plane tube containing saline and will be transferred immediately to the central research laboratory to be processed
- interventionNames
- Diagnostic Test: Detection of expression of SOCS3 gene
- Diagnostic Test: Detection of expression of IFN-α gene
- Diagnostic Test: Detection of expression of IFN-β gene
- label
- healthy volunteers
- description
- Under complete sterile precautions, Skin biopsy will be taken from healthy volunteers of the control group via 2 mm disposable punches . The specimen will be put in sterile plane tube containing saline and will be transferred immediately to the central research laboratory to be processed
- interventionNames
- Diagnostic Test: Detection of expression of SOCS3 gene
- Diagnostic Test: Detection of expression of IFN-α gene
- Diagnostic Test: Detection of expression of IFN-β gene
Primary outcomes (3)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * The study will include patients with cutaneous warts of various types aged 18-50 years old. Exclusion Criteria: * 1\. Pregnancy 2. Lactation 3. Patient on anti-inflammatory and antioxidant drugs 4. Skin infections, other than warts 5. Skin diseases 6. Systemic infection. 7. Malignancies
References
Publications (1)
- BACKGROUNDFeng M, Xie T, Li Y, Zhang N, Lu Q, Zhou Y, Shi M, Sun J, Zhang X. A balanced game: chicken macrophage response to ALV-J infection. Vet Res. 2019 Mar 6;50(1):20. doi: 10.1186/s13567-019-0638-y. PMID 30841905