Clinical trial · Interventional
Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Esophageal Carcinoma
Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Locally Advanced Esophageal Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective study aims to clarify the clinical efficacy and survival prognosis of neoadjuvant immune checkpoint inhibitor (ICI) combined with chemotherapy for esophageal cancer. It also explores predictive biomarkers and potential therapeutic targets for locally advanced esophageal cancer based on plasma metabolomics and peripheral blood immune cell clustering analysis. Each patient received 2-3 cycles of neoadjuvant immunotherapy with programmed cell death 1 (PD-1) blockade in combination with albumin paclitaxel and platinum. Exploratory analysis of plasma metabolomics combined with peripheral blood subsets of immune cells can reveal biomarkers that predict the efficacy and prognosis of patients undergoing neoadjuvant immunotherapy for locally advanced esophageal cancer, which also provide new ideas for the selection of immune adjuvants and therapeutic targets in ICIs combination therapy strategies.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Carcinoma | Esophageal Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Neoadjuvant Immunotherapy | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Albumin paclitaxel | Drug | — | UNRESOLVED |
| Carboplatin/Nedaplatin | Drug | — | UNRESOLVED |
| PD-1 blockade | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Neoadjuvant PD-1 Blockade Plus Chemotherapy
- description
- PD-1 blockade, 200 mg, IV., every 3 weeks, 2-3 cycles； Albumin paclitaxel, 300 mg/m2, IV., every 3 weeks, 2-3 cycles； Carboplatin/Nedaplatin, area under the curve = 5, IV., every 3 weeks, 2-3 cycles.
- interventionNames
- Drug: PD-1 blockade
- Drug: Albumin paclitaxel
- Drug: Carboplatin/Nedaplatin
Primary outcomes (1)
- measure
- Disease-free survival (DFS)
- timeFrame
- 24 months
- description
- Disease-free survival was defined as the time from randomization until the first documented disease recurrence or death due to any cause.
Secondary outcomes (3)
- measure
- Pathologic complete remission (PCR)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 89 Years
Show eligibility criteria text
Inclusion Criteria: 1. age ≥ 18 years and ≤89 years; 2. pathological histological examination confirmed the diagnosis of esophageal squamous cell carcinoma and esophageal adenocarcinoma; 3. clinical stage II-IVA; 4. adequate organ function; 5. no previous chemotherapy or radiotherapy; 6. voluntarily signed informed consent. Exclusion Criteria: 1. the presence of concurrent malignancies that interfere with the prognosis of esophageal cancer; 2. patients with immunodeficiency or autoimmune diseases that seriously affect the body's immune system, such as those who test positive for HIV; 3. patients undergoing systemic corticosteroid or other immunosuppressive treatments; 4. patients with a history of allergy to the components of this test drug.
References
Publications (0)
Data not yet available