Clinical trial · Interventional
Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy
Preoperative Vaginal Dinoprostone Versus Misoprostone to Decrease Bleeding During Abdominal Myomectomy
NCT05761418CI-TRIAL-00064574completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Myoma;Uterus | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dinoprostone | Drug | — | UNRESOLVED |
| Misoprostol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Dinoprostone
- description
- Will receive 20 mg of Dinoprostone vaginally 2 hrs. preoperatively.
- interventionNames
- Drug: Dinoprostone
- type
- EXPERIMENTAL
- label
- Misoprostol
- description
- will receive 400 μg of Misoprostol vaginally 2 hrs. preoperatively.
- interventionNames
- Drug: Misoprostol
- type
- NO_INTERVENTION
- label
- control
- description
- received a placebo vaginally 2 hrs. preoperatively.
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 30 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Age 30-50 years * all cases with uterine fibroid not responding to medical treatment and indicated for myomectomy. Exclusion Criteria: * contraindications to dinoprostone or misoprostol, * active PID, * history of pelvic/ ovarian endometriosis, * females who had pre-operative mifepristone, GnRH analog or orally contraception drugs, earlier myomectomy.
References
Publications (0)
Data not yet available
No reference posted for this study.