Clinical trial · Interventional
Alterations of Gut Microbiome, Function, and Its Intervention After Defunctioning Ileostomy
Alterations of Gut Microbiome, Function, and Its Intervention After Total Mesorectal Excision With Defunctioning Ileostomy for Mid-low Rectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study focused on the alterations of gut microbiome and function during defunctioning ileostomy, and observed the effects of probiotic intervention on intestinal microbiome and function. The investigators looked forward to find the specific intestinal maladjusted flora from this work, which could provide a new scheme for the subsequent treatment of the damaged intestinal function and the reduction of the incidence of postoperative complication.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ileostomy - Stoma | — | UNRESOLVED | — |
| Intestinal Functional Disorder | — | UNRESOLVED | — |
| Microbial Disease | — | UNRESOLVED | — |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MIYAIRI 588 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- MIYAIRI 588 group
- description
- 4 tablets of MIYAIRI 588 were inserted into distal ileostomy once a week for 6 months.
- interventionNames
- Drug: MIYAIRI 588
- type
- NO_INTERVENTION
- label
- control group
- description
- The anastomosis stoma was followed up monthly in the outpatient department
Primary outcomes (1)
- measure
- Wexner incontinence score
- timeFrame
- 1 year
- description
- Assess defecation function，the score range is 0-20, 0 is normal, 20 is complete incontinence
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with primary rectal cancer received total mesolectal resection combined with defunctioning ileostomy. 2. Patients voluntarily sign informed consent. Exclusion Criteria: 1. Disease progression or death after surgery. 2. Patients with inflammatory bowl disease. 3. Patients need to be on antibiotics/other probiotics for a long time.
References
Publications (0)
Data not yet available