Clinical trial · Observational
US-guided RFA vs MWA in the Treatment of Benign Thyroid Nodules
US-guided Radiofrequency Ablation Versus Microwave Ablation in the Treatment of Benign Thyroid Nodules
NCT05758038CI-TRIAL-00064499unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To evaluate the clinical outcomes of RFA and MWA for benign thyroid nodules treatment
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Nodule (Benign) | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radiofrequency ablation/Microwave ablation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- group 1
- description
- Patients with benign thyroid nodules undergo RFA
- interventionNames
- Procedure: Radiofrequency ablation/Microwave ablation
- label
- group 2
- description
- Patients with benign thyroid nodule undergo MWA
- interventionNames
- Procedure: Radiofrequency ablation/Microwave ablation
Primary outcomes (3)
- measure
- symptoms score
- timeFrame
- 2 years
- description
- symptoms score will be assessed by (visual analogue scale) a score from 1 to 10 will be given by the patient according to each symptom including (neck pain , dysphagia , foreign body sensation , discomfort and cough) 1 is the minimum score indicating the best outcome and 10 is the maximum score indicating worst outcome
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Solid or mixed nodules with predominant solid component with benign pathological result from US guided fine needle aspiration (FNAC). * Symptomatic and/or cosmetic problems. * Clinical thyrotoxicosis and hyperthyroidism caused by autonomously functioning thyroid nodules (AFTNs) * Refusal or ineligible for surgery. * Anxiety about a malignant transformation. Exclusion Criteria: * Malignant nodules on US. * Cytological evidence for malignancy * Patients with abnormal coagulation profile. * previous surgery or medicine for the thyroid, and vocal cord palsy in the side contralateral to the target nodules.
References
Publications (4)
- BACKGROUNDRuss G, Ben Hamou A, Poiree S, Ghander C, Menegaux F, Leenhardt L, Buffet C. Learning curve for radiofrequency ablation of benign thyroid nodules. Int J Hyperthermia. 2021;38(1):55-64. doi: 10.1080/02656736.2021.1871974. PMID 33491515
- BACKGROUNDLiu YJ, Qian LX, Liu D, Zhao JF. Ultrasound-guided microwave ablation in the treatment of benign thyroid nodules in 435 patients. Exp Biol Med (Maywood). 2017 Sep;242(15):1515-1523. doi: 10.1177/1535370217727477. Epub 2017 Aug 28. PMID 28847173
- BACKGROUNDErturk MS, Cekic B, Celik M. Microwave Ablation of Benign Thyroid Nodules: Effects on Systemic Inflammatory Response. J Coll Physicians Surg Pak. 2020 Jul;30(7):694-700. doi: 10.29271/jcpsp.2020.07.694. PMID 32811597
- BACKGROUNDDeandrea M, Trimboli P, Garino F, Mormile A, Magliona G, Ramunni MJ, Giovanella L, Limone PP. Long-Term Efficacy of a Single Session of RFA for Benign Thyroid Nodules: A Longitudinal 5-Year Observational Study. J Clin Endocrinol Metab. 2019 Sep 1;104(9):3751-3756. doi: 10.1210/jc.2018-02808. PMID 30860579