Clinical trial · Observational
Microbial Colonization in Lung Cancer Patients
NCT05748795CI-TRIAL-00064446unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Primary Aim: -To determine the prevalence and pattern of bronchial colonization in patients presenting with lung cancer at the time of diagnosis Secondary Aim: -To assess the potential demographic, clinical, radiological and histological predictors of colonization in patients with lung cancer
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Microbial Colonization | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| bronchoscopy brochoalveolar lavage | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Prevalence of microbial colonization among the study population:
- timeFrame
- through the study completion , an average of 1 year
- description
- Colonization will be defined as isolation of microorganisms from bronchoscopic wash samples at a threshold of 102 cfu.mL-1, whereas infection will be considered at .105 cfu.mL-1 . Regardless of the amount, isolation of mycobacteria and non-commensal fungi will be considered as colonization or an infection depending on the species isolated.
- measure
- Predictors of microbial colonization among the study population:
- timeFrame
- through the study completion , an average of 1 year
- description
- Demographic, clinical, radiological and histological data will be examined using univariate and multivariate regression analysis to identify their potential predictability of the colonization in patients with lung cancer.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \> 18 years * Radiological findings on HRCT chest suggestive of lung cancer (lung mass, pulmonary nodules with , obstructive pneumonia, unexplained lung collapse, mediastinal lymphadenopathy) Exclusion Criteria: * Patients who demonstrate clinical, laboratory or radiological evidence of active pulmonary infection that requires antibiotic therapy * Patients in whom histological evidence of lung cancer can't be proven after histopathology * Patients deemed unfit for bronchoscopy * Uncorrected hypoxia under oxygen spo2 \<90% * Uncontrolled cardiac arrhythmias despite medical treatment and arrhythmias associated with haemodynamic compromise . * patient who has risk factors for abnormal coagulation * Undrained Pneumothorax * Asthma and Chronic obstructive pulmonary disease who had suffered exacerbation during the preceding 3 weeks * Myocardial infarction in the previous 4 weeks
References
Publications (14)
- BACKGROUNDChen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32. doi: 10.3322/caac.21338. Epub 2016 Jan 25. PMID 26808342
- BACKGROUNDGonzalez C, Johnson T, Rolston K, Merriman K, Warneke C, Evans S. Predicting pneumonia mortality using CURB-65, PSI, and patient characteristics in patients presenting to the emergency department of a comprehensive cancer center. Cancer Med. 2014 Aug;3(4):962-70. doi: 10.1002/cam4.240. Epub 2014 May 7. PMID 24802800
- BACKGROUNDD'Journo XB, Rolain JM, Doddoli C, Raoult D, Thomas PA. Airways colonizations in patients undergoing lung cancer surgery. Eur J Cardiothorac Surg. 2011 Aug;40(2):309-19. doi: 10.1016/j.ejcts.2010.11.036. Epub 2011 Jan 8. PMID 21216614
- BACKGROUNDLanoix JP, Pluquet E, Lescure FX, Bentayeb H, Lecuyer E, Boutemy M, Dumont P, Jounieaux V, Schmit JL, Dayen C, Douadi Y. Bacterial infection profiles in lung cancer patients with febrile neutropenia. BMC Infect Dis. 2011 Jun 27;11:183. doi: 10.1186/1471-2334-11-183. PMID 21707992
- BACKGROUNDLaroumagne S, Salinas-Pineda A, Hermant C, Murris M, Gourraud PA, Do C, Segonds C, Didier A, Mazieres J. [Incidence and characteristics of bronchial colonisation in patient with lung cancer: a retrospective study of 388 cases]. Rev Mal Respir. 2011 Mar;28(3):328-35. doi: 10.1016/j.rmr.2010.05.020. Epub 2011 Feb 3. French. PMID 21482336
- BACKGROUNDIoanas M, Angrill J, Baldo X, Arancibia F, Gonzalez J, Bauer T, Canalis E, Torres A. Bronchial bacterial colonization in patients with resectable lung carcinoma. Eur Respir J. 2002 Feb;19(2):326-32. doi: 10.1183/09031936.02.00236402. PMID 11866014
- BACKGROUND8. Zhou S, Zhao Q. Colonization of Streptococcus pneumoniae in Pneumonia Patients with Lung Cancer. Jundishapur Journal of Microbiology. 2018 Feb 28;11(2)