Clinical trial · Interventional
Multilevel Interventions to Increase Adherence to Lung Cancer Screening
NCT05747443CI-TRIAL-00099616Larchactive not recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Screening for lung cancer has the potential for a profound public health benefit. Repeat annual screening is necessary for early detection of lung cancer. The investigators will test two interventions which include patient education and reminders to improve adherence to lung cancer screening.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Lung Cancer Screening | Lung Neoplasm | PROBABILISTIC | 0.70 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Patient Education | Other | — | UNRESOLVED |
| Stepped Reminders | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Patient Video only
- description
- About 3 weeks after the index LDCT, the study Medical Assistant (MA) will deliver a link to the Patient Voices Video, an educational video about lung cancer screening.
- interventionNames
- Other: Patient Education
- type
- EXPERIMENTAL
- label
- Stepped Reminders only
- description
- Prior to patient's next LDCT scan is due, MA begins Stepped Reminders intervention: MA pends LDCT orders to PCP to sign. MA sends reminders to patient when order is placed and follows up by phone if patient has not scheduled LDCT.
- interventionNames
- Other: Stepped Reminders
- type
- EXPERIMENTAL
- label
- Patient Video and Stepped Reminders
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 78 Years
Show eligibility criteria text
Inclusion Criteria: * KPWA members * Aged 50-78 years * Have a negative screening LDCT scan * Speak English or Spanish * Meet US Preventive Services Task Force guidelines Exclusion Criteria: * Patients who were previously diagnosed with lung cancer, * Patients who have a positive scan, * Patients who have an indicator for interpreter services, except for Spanish
References
Publications (5)
- DERIVEDWernli KJ, Anderson ML, Palazzo L, Luce C, Bezman N, Rogers K, Chin M, Gao H, Ralston J, Su YR, Carter-Bawa L, Triplette M, Tuzzio L, Vasavada A, Green BB. Health Communication and Stepped Reminders Interventions for Lung Cancer Screening: A Randomized Clinical Trial. JAMA Intern Med. 2026 Aug 10. doi: 10.1001/jamainternmed.2026.3666. Online ahead of print. PMID 42574003
- DERIVEDVasavada A, Palazzo L, Luce C, Sanchez M, Triplette M, Ralston JD, Carter-Bawa L, Green BB, Gao H, Li CI, Anderson ML, Su YR, Rogers K, Wernli KJ. Understanding older adults' perceptions and attitudes toward digital health and technology in a lung cancer screening-eligible population: a qualitative study. BMC Health Serv Res. 2026 Jul 21. doi: 10.1186/s12913-026-15124-7. Online ahead of print. PMID 42482048
- DERIVEDVasavada A, Palazzo L, Luce C, Sanchez M, Triplette M, Ralston JD, Carter-Bawa L, Green BB, Gao H, Li CI, Anderson ML, Su YR, Rogers K, Wernli KJ. "It's coming whether we want it to or not": A qualitative exploration of older adults' comfort with and perceptions of technology and digital health. Res Sq [Preprint]. 2025 Nov 19:rs.3.rs-8001649. doi: 10.21203/rs.3.rs-8001649/v1. PMID 41333381
- DERIVEDWernli KJ, Anderson ML, Palazzo L, Luce C, Bezman N, Chin M, Gao H, Ralston JD, Rogers K, Su YR, Triplette M, Carter-Bawa L, Vasavada A, Jordan M, West M, Boler S, Green BB. Effectiveness of Health Communication Intervention to Improve Knowledge on Timeliness to Return for Annual Lung Cancer Screening: The Larch Trial. Chest. 2026 Feb;169(2):550-561. doi: 10.1016/j.chest.2025.07.4111. Epub 2025 Sep 10. PMID 40939933
- DERIVEDLuce C, Palazzo L, Anderson ML, Carter-Bawa L, Gao H, Green BB, Ralston JD, Rogers K, Su YR, Tuzzio L, Triplette M, Wernli KJ. A pragmatic randomized clinical trial of multilevel interventions to improve adherence to lung cancer screening (The Larch Study): Study protocol. Contemp Clin Trials. 2024 May;140:107495. doi: 10.1016/j.cct.2024.107495. Epub 2024 Mar 11. PMID 38467273