Clinical trial · Observational
Genetics of Appendix Cancer Study
Genetics of Appendix Cancer: The GAP Study
NCT05734430CI-TRIAL-00088689GAPrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The GAP Study is a prospective cohort study designed to comprehensively investigate genetic variations that may contribute to cancer development among individuals diagnosed with appendix/appendiceal cancer who are ages 18+ years.
Conditions
Conditions (15)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Appendiceal Adenocarcinoma | Appendix Adenocarcinoma | ALIAS | 0.90 |
| Appendiceal Cancer | Malignant Appendix Neoplasm | ALIAS | 0.90 |
| Appendiceal Carcinoid Tumor | — | UNRESOLVED | — |
| Appendiceal Mucinous Neoplasm | Appendix Mucinous Neoplasm | ALIAS | 0.90 |
| Appendiceal Neoplasm Malignant Secondary | — | UNRESOLVED | — |
| Appendiceal Neoplasms | Appendix Neoplasm | ALIAS | 0.90 |
| Appendix Adenocarcinoma | Appendix Adenocarcinoma | ONTOLOGY_EXACT | 0.98 |
| Appendix Cancer | Malignant Appendix Neoplasm | ALIAS | 0.90 |
| Appendix Cancer Metastatic | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Genetic profiling | Genetic | — | UNRESOLVED |
| Retrospective tissue procurement | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- GAP Social
- description
- Individuals ages 18+ years with an appendix cancer diagnosis in the United States.
- interventionNames
- Genetic: Genetic profiling
- Other: Retrospective tissue procurement
- label
- GAP Vanderbilt
- description
- Individuals ages 18+ years with an appendix cancer diagnosis seen at Vanderbilt.
- interventionNames
- Genetic: Genetic profiling
- Other: Retrospective tissue procurement
- label
- GAP Parent
- description
- Biological parents of active GAP (Social and Vanderbilt) Study participants.
- interventionNames
- Genetic: Genetic profiling
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: GAP Social * Known diagnosis of appendix cancer in the United States * Mentally and physically able to consent and participate in the study GAP Vanderbilt * Known diagnosis of appendix cancer * Diagnosed by and/or consulting with a physician/clinical provider participating in the GAP Study * Mentally and physically able to consent and participate in the study GAP Parent * Biological parents (mother and/or father) of individuals actively participating in the GAP Study * Residing in the United States * Mentally and physically able to consent and participate in the study Exclusion Criteria: * Women pregnant at the time of consent * Prisoners * Unable to provide informed consent * Unable to read, write, or complete questionnaires in English
References
Publications (3)
- BACKGROUNDHolowatyj AN, Washington MK, Tavtigian SV, Eng C, Horton C. Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer. JAMA Oncol. 2022 Nov 11;9(1):95-101. doi: 10.1001/jamaoncol.2022.5425. Online ahead of print. PMID 36368039
- BACKGROUNDHolowatyj AN, Overman MJ, Votanopoulos KI, Lowy AM, Wagner P, Washington MK, Eng C, Foo WC, Goldberg RM, Hosseini M, Idrees K, Johnson DB, Shergill A, Ward E, Zachos NC, Shelton D; Appendix Cancer Pseudomyxoma Peritonei (ACPMP) Research Foundation. Defining a 'cells to society' research framework for appendiceal tumours. Nat Rev Cancer. 2025 Apr;25(4):293-315. doi: 10.1038/s41568-024-00788-2. Epub 2025 Feb 20. PMID 39979656
- BACKGROUNDJanczewski LM, Browner AE, Cotler JH, Nelson H, Kakar S, Carr NJ, Hanna NN, Holowatyj AN, Goldberg RM, Washington MK, Asare EA, Overman MJ; American Joint Committee on Cancer Expert Panel on Cancers for the Lower Gastrointestinal Appendix Disease Site. Survival outcomes used to validate version 9 of the American Joint Committee on Cancer staging system for appendiceal cancer. CA Cancer J Clin. 2023 Nov-Dec;73(6):590-596. doi: 10.3322/caac.21806. Epub 2023 Jun 26. PMID 37358310