Clinical trial · Observational
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
NCT05730855CI-TRIAL-00069552completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leukoplakia, Oral | — | UNRESOLVED | — |
| Oral Lichen Planus | — | UNRESOLVED | — |
| Potentially Malignant Lesions | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Real-time Polymerase Chain Reaction technique | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Oral Lichen Planus
- interventionNames
- Diagnostic Test: Real-time Polymerase Chain Reaction technique
- label
- Leukoplakia
- interventionNames
- Diagnostic Test: Real-time Polymerase Chain Reaction technique
- label
- Healthy control
- interventionNames
- Diagnostic Test: Real-time Polymerase Chain Reaction technique
Primary outcomes (1)
- measure
- salivary expression of lncDQ786243 in OLP, Leukoplakia, control
- timeFrame
- 2 months
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * participants will be divided into 3 groups: Group I: patients suffering from oral lichen planus Group II: patients suffering from leukoplakia Group III: healthy subjects who are systemically free, non-smokers, and not suffering from any oral mucosal lesions. Exclusion Criteria: * Subjects taking any drugs inducing any changes that could affect the salivary flow. * Pregnant females. * Subjects have any allergies, infectious diseases or active dental abscesses during one month before saliva sampling. * Patients receiving any drugs related to the oral lesions in the past 6 month prior to sample collection.
References
Publications (1)
- DERIVEDAfifi S, Ibrahim S, Kotb AA, ElRefai S, Hafed L, Shaker O, Baz S, Shalaby R. Long noncoding RNA DQ786243 and miRNA146a as potential salivary biomarkers for selected oral potentially malignant disorders: a diagnostic accuracy study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2026 Jan;141(1):96-105. doi: 10.1016/j.oooo.2025.08.013. Epub 2025 Aug 27. PMID 40973523