Clinical trial · Observational
Correlation Between Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy
Correlation Between Early Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy
NCT05728788CI-TRIAL-00064440unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study was to explore the relationship between early myocardial injury caused by tumor drug therapy and intestinal microbial structure changes by echocardiographic two-dimensional speckle tracking technique and intestinal microflora structure detection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Therapy-related Cardiovascular Toxicity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Antitumor drugs | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients treated with antineoplastic agents
- description
- 50 patients treated with antineoplastic agents will be enrolled.
- interventionNames
- Drug: Antitumor drugs
Primary outcomes (1)
- measure
- At least a 10% decrease in the global longitudinal strain
- timeFrame
- 6 months
- description
- The primary endpoint is at least a 10% decrease in the global longitudinal strain, determined using cardiac 2D STE and compared with baseline.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * With malignant tumors * Will receive antitumor drugs * Could receive regular follow-up for 6 months * Written informed consent Exclusion Criteria: * Satisfactory echocardiographic images could not be obtained * Cardiomyopathy * Coronary artery disease * Heart failure * Arrhythmia requiring intervention * Moderate or severe valvular disease * Acute myocarditis * Refractory hypertension * Participating in other studies of drug intervention
References
Publications (0)
Data not yet available
No reference posted for this study.