Clinical trial · Observational
Predictors of Para-aortic Lymph Node Metastasis of Cervical Cancer
Predictors of Para-aortic Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer Based on the Pooled Analysis of Surgical Staging Results
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to identify predictive factors and to develop a risk model predicting para-aortic lymph node metastasis in patients with locally advanced cervical cancer based on the analysis of surgical staging results. The main questions it aims to answer are: * What are the risk factors to predict para-aortic lymph node metastasis in patients with locally advanced cervical cancer? * What is the indication for prophylactic extended-field radiation therapy in patients with locally advanced cervical cancer Individual data of patients with locally advanced cervical cancer treated with surgical staging at our institution from 2020 to 2022 were pooled analysed.Multivariate Logistic regression analysis was used to identify the predictive factors and to develop the prediction model.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Locally Advanced Cervical Cancer | Malignant Cervical Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| surgical staging | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- experimental group
- description
- locally advanced cervical cancer treated with surgical staging
- interventionNames
- Procedure: surgical staging
Primary outcomes (2)
- measure
- Predictors of para-aortic lymph node metastasis
- timeFrame
- 3 months
- description
- We evaluate the institutional database for medical records to identify patients who underwent surgical staging, then comprised the primary and the independent validation cohort, respectively. The variables were collected from each patient. We assess the bivariate relationship between each variable and para-aortic lymph node metastasis via logistic regression analysis. The potential predictive variables of a P-value\<0.05 on univariate analysis were considered as risk factors.
- measure
- The prediction model of para-aortic lymph node metastasis
- timeFrame
- 3 months
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * In 2018, the International Federation of Obstetrics and Gynecology (FIGO) stage was Ib3 IIA2-IVA; * It was treated initially without surgical and chemotherapy. * Squamous cell carcinoma, adenocarcinoma and adeno-squamous cell carcinoma were confirmed by histopathology. * Abdominal pelvic CT, MRI or PET/CT were performed before treatment. * Patients with successful surgical staging and the pathological data of para-aortic lymph node were obtained. Exclusion Criteria: * Patients were excluded if the histopathological type was not squamous cell carcinoma or Adenocarcinoma, and the data of LN status was not available.
References
Publications (0)
Data not yet available