Clinical trial · Interventional
The Effectiveness of Adding Braun Anastomosis to Standard Child Reconstruction After Pancreatoduodenectomy
The Effectiveness of Adding Braun Anastomosis to Standard Child Reconstruction to Reduce Delayed Gastric Emptying After Pancreatoduodenectomy (REMBRANDT): a Multicenter Randomized-controlled Trial
NCT05709197CI-TRIAL-00125319REMBRANDTcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial (REMBRANDT) is to evaluate the effectiveness of adding an extra connection (i.e. 'Braun anastomosis') after standard reconstruction in pancreatic head resection in reducing the incidence of delayed gastric emptying.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Delayed Gastric Emptying | — | UNRESOLVED | — |
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
| Pancreatic Disease | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Braun anastomosis | Procedure | — | UNRESOLVED |
| Standard Child reconstruction | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Braun anastomosis
- description
- Open pancreatoduodenectomy with Braun enteroenterostomy
- interventionNames
- Procedure: Braun anastomosis
- type
- OTHER
- label
- Standard Child reconstruction
- description
- Open pancreatoduodenectomy only
- interventionNames
- Procedure: Standard Child reconstruction
Primary outcomes (1)
- measure
- Delayed gastric emptying (DGE)
- timeFrame
- During hospitalization
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Undergoing open pancreatoduodenectomy * Provided informed consent * Age over 18 years Exclusion Criteria: * Insufficient control of the Dutch language to read the patient information and to fill out the questionnaires in Dutch hospitals * Previous bariatric surgery (such as Roux-en-Y gastric bypass, gastric sleeve) * Pregnancy * Bowel motility disorders * Minimally invasive pancreatoduodenectomy * Gastric outlet syndrome
References
Publications (1)
- DERIVEDStrijbos BTM, Hopstaken JS, Endo C, de Vries M, Atsma F, Adang E, van der Wees P, Besselink MGH, van Santvoort H, den Dulk M, Groot Koerkamp B, Mieog JSD, Zeverijn S, van Laarhoven CJHM, Stommel MWJ; Dutch Pancreatic Cancer Group. The effectiveness of adding Braun anastomosis to standard Child reconstruction to reduce delayed gastric emptying after pancreatoduodenectomy (REMBRANDT): study protocol for a multicentre randomised-controlled trial. Trials. 2025 Oct 2;26(1):387. doi: 10.1186/s13063-025-09051-x. PMID 41039614