Clinical trial · Observational
Retrospective Review of Esophageal Cancer at MSKCC
NCT05706558CI-TRIAL-00105057recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 10, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260910-000001
Summary
Brief summary (as posted)
Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Esophagus Cancer | Esophageal Neoplasm | PROBABILISTIC | 0.70 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Esophagectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Circumferential resection margin (CRM)
- description
- Participants will have a diagnosis of esophageal carcinoma and residual tumor \>1 mm from the CRM
- interventionNames
- Procedure: Esophagectomy
- label
- Circumferential resection margin (CRM)-close
- description
- Participants will have a diagnosis of esophageal carcinoma and residual tumor \>0-1 mm from the CRM
- interventionNames
- Procedure: Esophagectomy
- label
- Circumferential resection margin (CRM)+
- description
- Participants will have a diagnosis of esophageal carcinoma and residual tumor at the surgical CRM
- interventionNames
- Procedure: Esophagectomy
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy * Pathologic staged T3 tumors (pT3) Exclusion Criteria: * Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4) * Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma in situ without tumor invasion, * Patients undergoing salvage esophagectomy * Evidence of distant metastatic disease * Patients with a positive proximal or distal margin
References
Publications (0)
Data not yet available
No reference posted for this study.