Clinical trial · Interventional
Letrozole vs Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovarian Syndrome
Letrozole vs Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovarian Syndrome: Randomised Control Trial
NCT05702957CI-TRIAL-00063499completedPhase 2 / Phase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It was randomised controlled study to compare the efficacy of clomiphene and letrozole in polycystic ovarian syndrome(PCOS) women with infertility.The aim was to select more appropriate treatment for ovulation induction in PCOS women.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Infertility | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Clomiphene Citrate 50mg-150mg | Drug | — | UNRESOLVED |
| letrozole 2.5mg-7.5mg | Drug | Letrozole | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- letrozole
- description
- Patients were given letrozole 2.5 mg-7.5mg per day for 5 days started from 2nd day of menses.
- interventionNames
- Drug: letrozole 2.5mg-7.5mg
- type
- ACTIVE_COMPARATOR
- label
- Clomiphene citrate
- description
- Patients were given clomiphene citrate 50-150mg per day for 5 days started from 2nd day of the menses.
- interventionNames
- Drug: Clomiphene Citrate 50mg-150mg
Primary outcomes (1)
- measure
- Pregnancy rate
- timeFrame
- 5th week of cycle when periods missed
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Women age between 18-40 years. * Normal husband semen analysis. Exclusion Criteria: * All infertile couples who had other causes of infertility than PCOS. * Those who had recently taken these medications. * Any contraindication to use of drugs e.g renal or hepatic dysfunction, hypersensitivity to this drug. * BMI\>35 because obese women respond poorly to ovulation induction.
References
Publications (1)
- DERIVEDWasim T, Nasrin T, Zunair J, Irshad S. Efficacy of Letrozole vs Clomiphene Citrate for induction of ovulation in women with polycystic ovarian syndrome. Pak J Med Sci. 2024 Jan-Feb;40(1Part-I):78-83. doi: 10.12669/pjms.40.1.7971. PMID 38196458