Clinical trial · Interventional
Applicability of 3D-HDRA in Patients With Primary Liver Cancer: A Randomized Controlled Trial
Applicability of 3D Histoculture Drug Response Assay(3D-HDRA) in Patients With Primary Liver Cancer: A Randomized Controlled Trial
NCT05701436CI-TRIAL-00064393unknownPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This Randomized Controlled Trial was to clarity the clinical feasibility of 3D-HDRA results in guiding the drug use of interventional chemotherapy after primary liver cancer surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver, Cancer of, Primary Resectable | — | UNRESOLVED | — |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cisplatin | Drug | Cisplatin | ALIAS |
| Doxorubicin | Drug | Doxorubicin | ALIAS |
| Lobaplatin | Drug | — | UNRESOLVED |
| Lobaplatin, Raltitrexed | Drug | — | UNRESOLVED |
| Oxaliplatin | Drug | Oxaliplatin | ALIAS |
| Oxaliplatin, Leucovorin, fluorouracil | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- the test group
- description
- The test group received postoperative conventional treatment combined with precise transarterial chemoembolization based on 3D-HDRA results. Precise transarterial chemoembolization at 1-month intervals for 4 months after surgery.
- interventionNames
- Drug: Oxaliplatin
- Drug: Doxorubicin
- Drug: Lobaplatin
- Drug: Cisplatin
- Drug: Oxaliplatin, Leucovorin, fluorouracil
- Drug: Lobaplatin, Raltitrexed
- type
- ACTIVE_COMPARATOR
- label
- the control group
- description
- The control group received postoperative conventional treatment combined with Empirical transarterial chemoembolization. Empirical transarterial chemoembolization at 1-month intervals for 4 months after surgery.
- interventionNames
- Drug: Oxaliplatin
- Drug: Doxorubicin
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients voluntarily cooperated with the study and signed an informed consent form. 2. Any gender, age 18 or older, 75 or younger. 3. Patients who need to confirm the maximum tumor load (the maximum diameter of a single tumor lesion) before performing radical surgery; patients with a confirmed diagnosis of primary liver cancer after postoperative pathological histological examination. 4. Patients with R0 resection confirmed by imaging and pathology (no residual lesions and complete tumor resection after radical surgery). 5. Child-Pugh score of 5-7 (A or B), patients with a score of 7 must be free of ascites. 6. ECOG physical fitness status score of 0-1. 7. Women of childbearing age with a negative pregnancy test and willing to use effective contraception for the duration of the study. Exclusion Criteria: 1. Patients with recurrent liver cancer. 2. Patients with existing extrahepatic distant metastases (including local lymph node metastases or distant organ metastases: e.g., lung, brain, bone, etc.) at the time of diagnosis. 3. Treatment with other experimental drugs or other interventions after radical resection. 4. Patients with other malignant tumors that have not been cured within 5 years. 5. Patients with non-radical resections (R1 and R2 resections). 6. Patients with residual or recurrent lesions detected on imaging within 1-2 months after surgery. 7. Patients in whom death occurred within 30 days after surgery.
References
Publications (0)
Data not yet available
No reference posted for this study.