Clinical trial · Interventional
Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords
NCT05688488CI-TRIAL-00066215recruitingPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To provide a novel therapy idea and method to solve the clinical problem of postoperative adhesion of bilateral vocal cords, patients enrolled in this study will be applied with curcumin on both wound sites of bilateral vocal cords after the surgery on the bilateral vocal cord endoscopically.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glottic Carcinoma | Glottis Carcinoma | ALIAS | 0.90 |
| Glottic Web of Larynx | — | UNRESOLVED | — |
| Laryngeal Leucoplakia | — | UNRESOLVED | — |
| Laryngeal Papilloma | Laryngeal Squamous Papilloma | ALIAS | 0.90 |
| Laryngeal Polyp | — | UNRESOLVED | — |
| Laryngeal Stenosis | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Curcumin | Drug | — | UNRESOLVED |
| Mitomycin-C | Drug | Mitomycin | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Curcumin
- interventionNames
- Drug: Curcumin
- type
- ACTIVE_COMPARATOR
- label
- Mitomycin
- interventionNames
- Drug: Mitomycin-C
Primary outcomes (1)
- measure
- Number of participants with laryngeal web formation as assessed by videolaryngoscope
- timeFrame
- 1 year postsurgery
- description
- All participants received the videolaryngoscope every month post-surgery, and a laryngeal web is defined as a visible adhesion whose length reached 1 mm or greater.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with bilateral vocal cord diseases who are going to undergo resection of bilateral vocal cord lesions endoscopically. 2. Patients with bilateral vocal cord adhesion who are going to undergo incision of bilateral vocal cord adhesion endoscopically. Exclusion Criteria: 1. Patients with other laryngeal diseases. 2. Patients with cardiac and pulmonary insufficiency. 3. Patients unable to cooperate with the follow-up on time after surgery. 4. Patients who refuse to sign the informed consent after notification. 5. Patients who have a severe allergic disease or allergic history to a variety of drugs. 6. Other circumstances that are not appropriate to be included in the clinical trial.
References
Publications (0)
Data not yet available
No reference posted for this study.