Clinical trial · Interventional
Multiparametric Quantitative MRI and Response to Neoadjuvant Radiotherapy for Soft-tissue Sarcoma
Neoadjuvant Radiotherapy of Soft Tissue Sarcomas of Limbs and Trunk : Interest of Multiparametric Quantitative MRI for Response Assessment and Per-treatment Progression Prediction
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial is a prospective, monocentric, with minimal risks and constraints study, conducted in patients with Soft Tissue Sarcoma (STS) of the limbs and trunk with indication for neoadjuvant radiotherapy (RT). Patients will be treated by neoadjuvant RT and will have a pre-RT and a post-RT multiparametric quantitative Magnetic Resonance Imaging (MRI). A tumor resection will be performed 6 to 8 weeks post-RT and an anatomopathological observation of the surgical specimen will be performed. This study will allow to describe the initial remnographic characteristics and their evolution after neoadjuvant RT using quantitative multiparametric MRI (mpMRI).
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adult Soft Tissue Sarcoma | Adult Soft Tissue Sarcoma | ONTOLOGY_EXACT | 0.98 |
| Resectable Soft Tissue Sarcoma | Soft Tissue Sarcoma | CURATED_BROADER | 0.78 |
| Soft Tissue Sarcoma | Soft Tissue Sarcoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Neoadjuvant RT | Radiation | — | UNRESOLVED |
| Post-radiotherapy mpMRI | Other | — | UNRESOLVED |
| Pre-radiotherapy mpMRI | Other | — | UNRESOLVED |
| Tumor resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Pre- and post- radiotherapy multiparametric quantitative MRI
- description
- Patients with STS of the limbs and trunk will be accrued during the initial radiotherapy consultation radiotherapy (prior to receiving radiotherapy). Two quantitative multiparametric MRI will be performed. The first one will be acquired less than 14 days before the dosimetric scan, the second one 4 to 6 weeks after the end of the radiotherapy. A tumor resection will be performed 6 to 8 weeks post-RT and an anatomopathological observation of the surgical specimen will be performed.
- interventionNames
- Radiation: Neoadjuvant RT
- Other: Pre-radiotherapy mpMRI
- Other: Post-radiotherapy mpMRI
- Procedure: Tumor resection
Primary outcomes (4)
- measure
- Maximum axial dimension
- timeFrame
- Pre-radiotherapy mpMRI performed within 14 days before the dosimetric scan. Post-radiotherapy mpMRI performed 4 to 6 weeks after radiation therapy completion.
- description
- Evolution of the maximum axial dimension (mm) after neoadjuvant radiotherapy, obtained with quantitative multiparametric MRI
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
INCLUSION CRITERIA : * Patients 18 years of age or older; * Documented histologic diagnosis of soft tissue sarcoma of the limbs or trunk; * Validated indication for neoadjuvant radiotherapy, planned in the radiotherapy department of the Centre Léon Bérard; * No contraindication to Magnetic Resonance Imaging, * Signed informed consent; * Affiliation with a social security system or beneficiary of such a system. EXCLUSION CRITERIA : * Tumor considered as unresectable or patient considered as non-operable; * Desmoid tumor or dermatofibrosarcoma protuberans due to intermediate malignancy; * Rhabdomyosarcoma due to a different therapeutic management; * Multi-metastatic disease; * Pregnant or lactating woman, * Patient under guardianship, curatorship or deprived of liberty.
References
Publications (0)
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