Clinical trial · Interventional
How Effective is the Dose-graded Aerobic Training in Children Survivors of Acute Lymphoblastic Leukemia?
Effectiveness of a Dose-graded Aerobic Exercise Regimen on Cardiopulmonary Fitness and Physical Performance in Children Survivors of Acute Lymphoblastic Leukemia: A Randomized Clinical Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study was to evaluate the impact of a 12-week dose-graded aerobic exercise program (D-GAE) on cardiopulmonary fitness and physical performance in children survivors of acute lymphoblastic leukemia (ALL). A total of 58 ALL survivors were randomly assigned to the D-GAE group (n = 29, who underwent a combination of traditional physical rehabilitation and intensity- and duration-graded aerobic training three times per week for 12 weeks) or the control group (n = 29, who underwent only traditional physical rehabilitation). Cardiopulmonary fitness and physical performance were evaluated in both groups before and after treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Lymphoblastic Leukemia | Acute Lymphoblastic Leukemia | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dose-graded aerobic exercises | Other | — | UNRESOLVED |
| Traditional physical rehabilitation | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- D-GAE group
- description
- This group received a 12-week aerobic training in addition to the traditional physical rehabilitation.
- interventionNames
- Other: Dose-graded aerobic exercises
- type
- ACTIVE_COMPARATOR
- label
- Control group
- description
- This group received the traditional physical rehabilitation only
- interventionNames
- Other: Traditional physical rehabilitation
Primary outcomes (1)
- measure
- Peak oxygen uptake
- timeFrame
- 3 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 10 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Survivors of childhood ALL * Age of 10-18 years * Completion of maintenance therapy * Free of lower limb or spinal deformities * Not participating in regular exercise regimens in the past six months Exclusion Criteria: * Secondary malignancies * Significant musculoskeletal/neurological issues * Neurocognitive impairments
References
Publications (0)
Data not yet available