Clinical trial · Observational
Urine VOC Investigation in Bladder Cancer Diagnosis
Investigation of Urine Volatile Organic Compounds as Novel Diagnostic Biomarker in Bladder Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this study to investigate the volatile organic compounds (VOCs) in the urine samples of both healthy individual and bladder cancer patients, using gas chromatography - mass spectrometry. Researchers aim to find a set of certain VOCs specific to bladder cancer and use this set to construct a diagnostic model that can help diagnosing bladder cancer. Participants will be asked to collect their early morning midstream urine in a predesignated container. Researchers will compare urine VOCs from bladder cancer patients and healthy individuals to see if there is any VOC whose concentration differ significantly among the two groups.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Cancer | Malignant Bladder Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| analysis of urine volatile organic compounds | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patients with confirmed bladder tumor
- description
- Patients with bladder tumor, confirmed by cystoscopy and radiology. Age ranging from 18 to 80 years old. Women of childbearing age should have negative urine pregnancy test.
- interventionNames
- Diagnostic Test: analysis of urine volatile organic compounds
- label
- Healthy volunteers
- description
- Individuals with no known disease and normal urinalysis. Age ranging from 18 to 80 years old. Women of childbearing age should have negative urine pregnancy test.
- interventionNames
- Diagnostic Test: analysis of urine volatile organic compounds
Primary outcomes (1)
- measure
- Urine volatile organic compounds composition of all urine samples
- timeFrame
- immediately after GC-MS analysis has been finished
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * bladder tumor confirmed by cystoscopy and radiology * women of childbearing age with negative urine pregnancy test result * willing to participate in this trial and sign the informed consent form Exclusion Criteria: * patient with 1) uncontrollable urinary tract infection; 2) severe systemic disease; 3) history of malignancy within the past 5 years; 4) pregnancy or lactation * patient involved in other clinical trials * other situations researcher considered to be ineligible for this trial
References
Publications (0)
Data not yet available