Clinical trial · Interventional
Magnesium Sulphate Versus Ketamine as an Adjuvant to Bupivacaine in Pectoral Nerve Block During Mastectomy
Efficacy Of Magnesium Sulphate Versus Ketamine as an Adjuvant to Bupivacaine in Pectoral Nerve Block During Mastectomy : Comparative Controlled , Randomized Double-Blind Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
There are no published article that compare magnesium sulfate and ketamine as adjuvants to bupivacaine in PECS block , so the aim of this study is to evaluate the efficacy of Magnesium sulfate versus ketamine when added to local anesthetic ( Bupivacaine) in pectoral nerve block during mastectomy and detect which of these drugs has the more effective analgesic effect and decrease opioid consumption .
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast | — | UNRESOLVED | — |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Use of Bupivacaine in pectoral nerve block in mastectomy | Drug | — | UNRESOLVED |
| use of Ketamine as adjuvants to bupivacaine in pectoral nerve block in mastectomy | Drug | — | UNRESOLVED |
| Use of Magnesium Sulfate as adjuvants to bupivacaine in pectoral nerve block in mastectomy | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Group A (control group )
- description
- Patients will be given 30 mL of 0.25% bupivacaine hydrochloride in pectoral nerve block .
- interventionNames
- Drug: Use of Bupivacaine in pectoral nerve block in mastectomy
- type
- ACTIVE_COMPARATOR
- label
- Group B ( Ketamine group)
- description
- Patients will be given 30 mL of 0.25% bupivacaine hydrochloride plus ketamine hydrochloride (1 mg/kg) in pectoral nerve block .
- interventionNames
- Drug: use of Ketamine as adjuvants to bupivacaine in pectoral nerve block in mastectomy
- type
- ACTIVE_COMPARATOR
- label
- Group C (Magnesium sulfate group)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 30 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Female patient * Age from 30 to 70 years old * American Society of Anesthesiologists (ASA) I-II Exclusion Criteria: * Cognitive impairment * History of alcohol or drug abuse * Allergy to the studied drugs * Patients with coagulation disorders * Block site infection * Uncontrolled diabetes mellitus * Uncontrolled hypertension * Body Mass Index( BMI) more than 30 kg/m2
References
Publications (1)
- RESULTBashandy GM, Abbas DN. Pectoral nerves I and II blocks in multimodal analgesia for breast cancer surgery: a randomized clinical trial. Reg Anesth Pain Med. 2015 Jan-Feb;40(1):68-74. doi: 10.1097/AAP.0000000000000163. PMID 25376971