Clinical trial · Interventional
Volumetric Analysis of Bone Following Jaw Cysts Enucleation With and Without Alb-PRF
Three-dimensional Volumetric Analysis of Bone Regeneration Following Jaw Cysts Enucleation With and Without Autologous Albumin Gel-platelet-rich Fibrin Mixture (A Randomized Controlled Clinical Trial)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cyst is the main cause for longstanding swelling in the mandible or the maxilla, its enlargement usually results in resorption and weakening of bone. Thus the treatment of the cysts is essential to preserve the bone and the adjacent vital structures. Healing of the bone defect and its surrounding soft tissues is a critical issue that needs concerns. Although the Platelet rich fibrin has promising effects in wound healing, it can resorb during 10-14 days. Thus a new autologous platelet concentrate is introduced by Kawasi et al that can remain stable for 4-6 months called albumin PRF.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Jaw Cysts | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Enucleation with albumin PRF | Other | — | UNRESOLVED |
| Enucleation without albumin PRF | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Enucleation with albumin PRF
- interventionNames
- Other: Enucleation with albumin PRF
- type
- ACTIVE_COMPARATOR
- label
- Enucleation without albumin PRF
- interventionNames
- Other: Enucleation without albumin PRF
Primary outcomes (3)
- measure
- Change in pain score
- timeFrame
- Up to 1 week
- description
- It will be assessed on 3rd and 7th day through a 10-point Visual Analogue Scale (VAS)(25) (0-1= None, 2-4= Mild, 5-7= Moderate, 8-10= Severe)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients suffering from jaw cystic cavity volume greater than 1cm3 * Patients with no gender predilection that agreed to present for follow-up visits for a minimum postoperative period of 6 months. * Cystic lesion that requires removal under local or general anaesthesia. Exclusion Criteria: * Medically compromised patients contradicting operation. * Patients with history of chemotherapy or radiotherapy. * Patients with low level of platelet count. * Patients with anticoagulant therapy. * Patients who are unable to attend follow up appointments
References
Publications (1)
- DERIVEDShokry MMEM, Melek LNF, Amer TA. Three-dimensional volumetric analysis of bone regeneration following jaw cyst enucleation with and without an autologous albumin gel-platelet-rich fibrin mixture (Alb-PRF): a randomized controlled clinical trial. BMC Oral Health. 2025 May 8;25(1):693. doi: 10.1186/s12903-025-06027-w. PMID 40340767