Clinical trial · Observational
Inflammatory Index as a Predictor for Endometrial Cancer: an Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is a prospective observational trial. Primary goal is identification of an association between alteration of systemic inflammation indices, such as neutrophil-to-lymphocyte ratio (NLR), platelet-t- lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (MRL) and patients risk classification according to European Guidelines. The population is represented by all women being admitted to the Gynecology Ward, through Emergency, who are affected by endometrial cancer. Participants will undergo surgery, and freely express their consent to participate in the study.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Neoplasms | Endometrial Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Inflammatory Response | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Surgical staging of endometrial cancer | Other | — | UNRESOLVED |
| Venous blood sample | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Endometrial cancer patients
- description
- At least 18-year-old patients histologically diagnosed with endometrial cancer who will undergo surgical staging of disease after performing full-body CT-scan 30 days before the enrollment.
- interventionNames
- Diagnostic Test: Venous blood sample
- Other: Surgical staging of endometrial cancer
Primary outcomes (5)
- measure
- Grading
- timeFrame
- 30 days after surgery
- description
- Anatomic pathology report of cell anaplasia in the sampled tumor
- measure
- Staging
- timeFrame
- 30 days after surgery
- description
- Anatomic pathology report of extent to which the cancer has spread
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients histologically diagnosed with endometrial cancer. * Patients undergoing surgical staging of the disease. * Patients undergoing full-body CT-scan 30 days before enrollment. * At least 18-year-old patients. Exclusion Criteria: * Unfit to plead. * Patients with chronic inflammatory diseases (IBDs; rheumatic conditions). * Synchronous tumors or cancer diagnosis in the previous 3 years. * Patients undergoing steroid therapy in the last 30 days prior to recruitment
References
Publications (1)
- DERIVEDRonsini C, Iavarone I, Vastarella MG, Della Corte L, Andreoli G, Bifulco G, Cobellis L, de Franciscis P. Additional Risk Factors Lead to a Measurable Inflammatory Response in Stage I Endometrial Cancer-A Prospective Multicentric Observational Study. Indian J Surg Oncol. 2025 Dec;16(6):1474-1481. doi: 10.1007/s13193-025-02228-5. Epub 2025 Feb 24. PMID 41415794