Clinical trial · Interventional
Acute Immunological Effects of Exercise in Cancer Patients
ACTIVE- Acute Effects of a Single Physical Exercise Intervention on Immune Cells and Inflammation in Cancer Patients and a Healthy Comparison Group
NCT05656651CI-TRIAL-00111674ACTIVEactive not recruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the study is to evaluate and compare immune response to a single exercise intervention in cancer patients and healthy age-maged individuals.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| High intensity interval exercise training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Cancer patients
- description
- Single exercise intervention following a HIIT protocol, duration \~20 mins
- interventionNames
- Behavioral: High intensity interval exercise training
- type
- ACTIVE_COMPARATOR
- label
- Healthy adults
- description
- Single exercise intervention following a HIIT protocol, duration \~20 mins
- interventionNames
- Behavioral: High intensity interval exercise training
Primary outcomes (1)
- measure
- Number of Natural Killer Cells
- timeFrame
- Change from pre Intervention to immediately after intervention and 1 hour post intervention
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
Show eligibility criteria text
Inclusion Criteria: * Adolescents and young adults \>14 years of age * undergoing acute cancer treatment (chemotherapy) * signed informed consent Exclusion Criteria: * Inability to follow and implement test instructions * medical contraindication to HIIT on cycle ergometer * chemotherapeutic treatment 48 h prior * Hb \<8g/dl; platelets \< 20,000/ul.
References
Publications (2)
- DERIVEDKiehl F, De Lazzari N, Beller R, Deppe I, Bennstein SB, Botzenhardt S, Salvador Comino MR, Tewes M, Gotte M. High-Intensity Interval Training Boosts Immune Cells in Advanced Cancer Patients and Healthy Controls: Implications for Cancer Care. Cancer Med. 2026 Jun;15(6):e71977. doi: 10.1002/cam4.71977. PMID 42233178
- DERIVEDDeppe I, Beller R, Kiehl F, Lazzari N, Bennstein SB, Reinhardt D, Dirksen U, Gotte M. The impact of a single HIIT intervention on the mobilization of NK cells and ILCs in adolescents and young adults (AYA) undergoing cancer treatment: an interventional controlled trial. BMC Cancer. 2025 Apr 14;25(1):689. doi: 10.1186/s12885-025-14058-3. PMID 40229731