Clinical trial · Observational
Evaluation of the Use of the FUR to Quantify Tumor Glucose Consumption in Oncologic PET
Evaluation of the Fractional Uptake Rate (FUR) in 18F-FDG PET/CT to Assess Tumour Metabolic Activity
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this study is to evaluate the use of new method to quantify the amount of sugar a tumor consumes using PET/CT. The main questions it aims to answer are: * Is the new quantification method superior with respect to the method currently used in the clinic? * Does the new quantification method provide accurate assessment of the sugar consumption of tumours? Participants who will undergo a standard care FDG PET/CT scan will in additional receive a dynamic PET/CT scan prior to the standard care scan. In addition blood samples will be drawn at three time points during the examination.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| FDG PET/CT | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Oncologic patients
- description
- Lymphoma and lung cancer patients will undergo an additional dynamic FDG PET/CT examination on top of their standard care PET/CT examination. In addition, blood samples will be drawn at three time points
- interventionNames
- Diagnostic Test: FDG PET/CT
Primary outcomes (1)
- measure
- Superiority of the FUR compared to the SUV
- timeFrame
- Time of PET examination
- description
- The correlation between the fractional uptake rate (FUR) and the metabolic glucose consumption (Km) will be compared to the correlation between the standardized uptake value (SUV) and Km
Secondary outcomes (2)
- measure
- FUR validation to quantify tumour metabolic activity
- timeFrame
- Time of PET examination
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who receive an 18F FDG PET/CT scan as part of standard care * Be competent and be 18 years of age or older Exclusion Criteria: * Diabetes (fasted blood glucose \> 7 mmol/L) * Not fasted \> 4 hours * Physical exercise within 24 hours * Earlier treatment for carcinoma with radio/chemo-therapy * Active inflammation (fever \> 38 degrees, CRP \> 5) * Any condition or medical indication (such as claustrophobia) that indicates that the patient will not be able to lie still for the duration of the dynamic PET/CT examination * Pregnant or breast feeding
References
Publications (0)
Data not yet available