Clinical trial · Interventional
Effect of an Oral Nutritional Supplement on Muscle Mass During Anticancer Treatment
Muscle Mass in Patients With Colorectal or Lung Cancer When Receiving an Oral Nutritional Supplement During Anti-cancer Treatment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Malnutrition and low muscle mass (sarcopenia) are common problems in patients with cancer. However, a low muscle mass is associated with negative clinical outcomes in patients with cancer. Therefore, it is very important to maintain muscle mass in this population. This study aims to investigate the effect of an oral nutritional supplement on skeletal muscle mass during anti-cancer treatment.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer (CRC) | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Non-small Cell Lung Cancer (NSCLC) | Lung Non-Small Cell Carcinoma | ALIAS | 0.85 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| an enriched high protein and high energy oral nutrition supplement (ONS) | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Test product
- description
- An enriched high protein and high energy oral nutrition supplement (ONS)
- interventionNames
- Dietary Supplement: an enriched high protein and high energy oral nutrition supplement (ONS)
- type
- ACTIVE_COMPARATOR
- label
- Control product
- description
- standard isocaloric high energy normal protein isocaloric ONS
- interventionNames
- Dietary Supplement: an enriched high protein and high energy oral nutrition supplement (ONS)
Primary outcomes (1)
- measure
- Change in cross-sectional skeletal muscle mass area on the third vertebral level (L3) [cm2]
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of stage III or IV colorectal or non-small cell lung cancer * Scheduled for the first cycle of any line of a systemic treatment: chemotherapy, concurrent chemoradiotherapy, immunotherapy or targeted treatment with a planned duration of at least 9 weeks * Performance status Eastern Cooperative Oncology Group (ECOG) score 0 or 1 * Age ≥ 18 years Exclusion Criteria: * Weight loss \>10% in the last 6 months * Body Mass Index \> 30.0 kg/m2 * Life expectancy \< 3 months * Receiving enteral (tube) or parenteral nutrition * Presence of ileostoma or ileal pouch (except for an ileostomy at or near the terminal ileum which does not affect absorption of nutrients other than sodium, potassium, and water, in the opinion of the investigator) * Allergy to cow's milk protein, soy or fish, requiring a fibre-free diet or suffering galactosemia or lactose intolerance * Known pregnancy or lactation * Current alcohol or drug abuse in the opinion of the investigator * Wearing an electronic implant and/or pacemaker * Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements * Participation in any other studies involving investigational or marketed products concomitantly or within 14 days prior to entry into the study
References
Publications (0)
Data not yet available