Clinical trial · Interventional
Study of LM-305 in Patients With Relapsed or Refractory Multiple Myeloma (RRMM) and Other Plasma Cell Diseases
A Phase I/II, Open-Label, Multiple Centre Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of LM-305 in Patients With Relapsed or Refractory Multiple Myeloma (RRMM) and Other Plasma Cell Diseases
NCT05647512CI-TRIAL-00071468withdrawnPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): According to sponsor strategy
Summary
Brief summary (as posted)
A Phase I/II Study of LM-305 in Patients with Relapsed or Refractory Multiple Myeloma (RRMM)
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Other Plasma Cell Diseases | — | UNRESOLVED | — |
| Relapsed or Refractory Multiple Myeloma | Multiple Myeloma | PROBABILISTIC | 0.70 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexamethasone | Drug | Dexamethasone | ALIAS |
| LM-305 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- LM-305 Dose Escalation
- description
- Administered intravenously
- interventionNames
- Drug: LM-305
- type
- EXPERIMENTAL
- label
- LM-305 Combination Expansion
- description
- LM-305 Administered intravenously Dexamethasone Orally
- interventionNames
- Drug: LM-305
- Drug: Dexamethasone
Primary outcomes (2)
- measure
- Dose limiting toxicity (DLT)
- timeFrame
- Cycle 1 of each cohort. Duration of one cycle is 21 days
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Subjects will be enrolled into the study only if they meet all of the following inclusion criteria: 1. Subjects who are fully informed of the purpose, nature, method and possible adverse reactions of the study, and are willing to participate in the study and sign the informed consent form (ICF) prior to any procedure. 2. Aged ≥18 years old when sign the ICF, male or female. 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1。 4. Life expectancy ≥ 6 months. 5. Subjects must show appropriate organ and marrow function in laboratory examinations Exclusion Criteria: Subjects will be excluded from the study, if they meet any of the following criteria: 1. A history of other malignant tumors than multiple myeloma within 3 years prior to first dosing 2. Subjects who have severe cardiovascular disease。 3. Use of any live attenuated vaccines within 28 da ys prior to 1st dosing of IMP. 4. Child-bearing potential female who have positive results in pregnancy test or are lactating. 5. Subject who is judged as not eligible to participate in this study by the investigator.
References
Publications (0)
Data not yet available
No reference posted for this study.