Clinical trial · Interventional
PREHAB - Improving Condition Before Surgery
PREHABILITATION During Neoadjuvant Therapy in Patients With Cancer of the Upper Digestive Tract and Rectum
NCT05646043CI-TRIAL-00073070unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The pilot research project is focused on the feasibility of a prehabilitation program for two groups of diagnoses (esophageal and stomach cancer, rectal cancer).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer, Digestive System | Malignant Digestive System Neoplasm | ALIAS | 0.90 |
| Cancer, Rectum | Rectal Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Muscle strength training | Behavioral | — | UNRESOLVED |
| Physical training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Patients with cancer of the digestive system
- description
- Patients with cancer of the digestive system (oesophageal and stomach cancer) will be enrolled in this study arm.
- interventionNames
- Behavioral: Physical training
- Behavioral: Muscle strength training
- type
- ACTIVE_COMPARATOR
- label
- Patients with cancer of the rectum
- description
- Patients with cancer of the rectum will be enrolled in this study arm.
- interventionNames
- Behavioral: Physical training
- Behavioral: Muscle strength training
Primary outcomes (3)
- measure
- Number of enrolled patients
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * radically operable locally advanced cancer of the esophagus, esophagogastric junction, stomach * radically operable locally advanced carcinoma of the rectum * the patient is able to handle the planned surgical resection procedure * planned preoperative neoadjuvant therapy * age \> 18 years * the ability to complete a spiroergometric examination * the ability to carry out a prehabilitation program consent to participate in the study confirmed by signing the informed consent Exclusion Criteria: * contraindications for spiroergometric examination * limitation on the part of the locomotor system to spiroergometric examination or daily exercise (e.g. amputation, severe gonarthrosis, coxarthrosis) * inoperability determined by the interdisciplinary team * inability to manage the planned operational performance * acute surgical performance * synchronous malignant disease * multivisceral resection * planned non-surgical therapeutic procedure * incomplete data
References
Publications (1)
- DERIVEDChmelova I, Pastucha D, Hudecek T, Guran Z, Ciecotkova S, Martinek L, Zubikova J, Matlova A, Dolezel J, Salounova D, Chmelo J. Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum-the study protocol. Front Sports Act Living. 2025 Feb 3;6:1495398. doi: 10.3389/fspor.2024.1495398. eCollection 2024. PMID 39963182